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Related Concept Videos

Stereotaxic Surgery for Implantation of Microelectrode Arrays in the Common Marmoset (Callithrix jacchus)10:53

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This work presents a protocol to perform a stereotaxic, neurosurgical implantation of microelectrode arrays in the common marmoset. This method specifically enables electrophysiological recordings in freely behaving animals but can be easily adapted to any other similar neurosurgical intervention in this species (e.g., cannula for drug administration or electrodes for brain...
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We have developed a whole-cortical electrocorticographic array for the common marmoset that continuously covers almost the entire lateral surface of cortex, from the occipital pole to the temporal and frontal poles. This protocol describes a chronic implantation procedure of the array in the epidural space of the marmoset...
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Related Experiment Video

Updated: Jan 20, 2026

Stereotaxic Surgery for Implantation of Microelectrode Arrays in the Common Marmoset Callithrix jacchus
10:53

Stereotaxic Surgery for Implantation of Microelectrode Arrays in the Common Marmoset Callithrix jacchus

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Spinal cord neural interfacing in common marmosets (Callithrix jacchus).

Noeline W Prins1, Ramanamurthy Mylavarapu1, Alden M Shoup1

  • 1Department of Biomedical Engineering, University of Miami, 1251 Memorial Dr, MEA 203, Coral Gables, FL 33146, United States of America.

Journal of Neural Engineering
|September 4, 2019
PubMed
Summary

Researchers developed a spinal cord neural interface for common marmosets, a small non-human primate (NHP) model. This technology aims to restore motor control and function for individuals with spinal cord injuries.

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A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus
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Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset
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Last Updated: Jan 20, 2026

Stereotaxic Surgery for Implantation of Microelectrode Arrays in the Common Marmoset Callithrix jacchus
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A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus
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Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset
04:43

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Primate Models

Background:

  • Spinal cord injury (SCI) severely impacts quality of life, with limited restorative options.
  • Brain-machine interfaces show promise for restoring function, but spinal cord interfacing offers complementary advantages.
  • Non-human primate (NHP) models are crucial for developing neural interfaces, yet smaller models present unique challenges.

Purpose of the Study:

  • To develop a spinal cord neural interface for recording motor signals in a common marmoset (Callithrix jacchus) model.
  • To investigate the feasibility of using smaller NHPs for high-cervical spinal cord signal acquisition.
  • To establish a platform for understanding motor control signal transformation within the spinal cord.

Main Methods:

  • Detailed surgical techniques for electrode and connector placement in the high cervical spinal cord of marmosets.
  • Behavioral training protocols tailored for the marmoset model.
  • Multi-channel extracellular recording methodologies and strategies to overcome recording challenges in small NHP models.

Main Results:

  • Demonstrated feasibility of chronic spinal cord signal recording in a small NHP model.
  • Identified and discussed major recording failure mechanisms encountered during the study.
  • Provided insights into electrode specifications and modifications for accessing specific neuronal populations.

Conclusions:

  • Marmosets are a viable model for spinal cord neural interface research, bridging the gap between rodent and larger NHP studies.
  • Successful spinal cord interfacing in marmosets can yield valuable data on motor control pathways.
  • This research lays the groundwork for advanced prosthetic and restorative technologies for SCI patients.