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Updated: Jan 20, 2026

Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface
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Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental

Takuji Tomimatsu1, Kazuya Mimura2, Shinya Matsuzaki2

  • 1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. tomimatsu@gyne.med.osaka-u.ac.jp.

International Journal of Molecular Sciences
|September 5, 2019
PubMed

Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation, is the leading cause of maternal and perinatal morbidity and mortality. Maternal endothelial dysfunction caused by placental factors has long been accepted with respect to the pathophysiology of preeclampsia. Over the past decade, increased production of placental antiangiogenic factors has been identified as a placental factor leading to maternal endothelial dysfunction and systemic vascular dysfunction. This review summarizes the recent advances in understanding the molecular mechanisms of endothelial dysfunction caused by placental antiangiogenic factors, and the novel clinical strategies based on these discoveries.

Keywords:
angiogenic imbalancearterial stiffnessendothelial dysfunctionplacental growth factorpreeclampsiasoluble fms-like tyrosine kinase 1systemic vascular dysfunctionvascular endothelial growth factor

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