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Published on: January 31, 2020
The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer
Beatriz Martínez-Poveda1,2, José Antonio Torres-Vargas3, María Del Carmen Ocaña3
1Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, Andalucía Tech, 29071 Málaga, Spain. bmpoveda@uma.es.
Abstract:
Diet-based chemoprevention of cancer has emerged as an interesting approach to evade the disease or even target its early phases, reducing its incidence or slowing down tumor progression. In its basis in the essential role of angiogenesis for tumor growth and metastasis, angioprevention proposes the use of inhibitors of angiogenesis in cancer prevention. The anti-angiogenic potential exhibited by many natural compounds contained in many Mediterranean diet constituents makes this dietary pattern especially interesting as a source of chemopreventive agents, defined within the angioprevention strategy. In this review, we focus on natural bioactive compounds derived from the main foods included in the Mediterranean diet that display anti-angiogenic activity, as well as their possible use as angiopreventive agents.
Insights
The Mediterranean diet offers natural compounds that can inhibit angiogenesis, a key process in tumor growth. These compounds show promise for cancer prevention through a strategy called angioprevention.
Area of Science:
- Oncology
- Nutritional Science
- Pharmacology
Background:
- Cancer chemoprevention is explored through diet, targeting early disease phases.
- Angiogenesis, crucial for tumor growth and metastasis, is a target for prevention.
- The Mediterranean diet is rich in compounds with anti-angiogenic properties.
Purpose of the Study:
- To review natural bioactive compounds from the Mediterranean diet with anti-angiogenic activity.
- To explore their potential use in angioprevention strategies for cancer prevention.
Main Methods:
- Literature review of studies on Mediterranean diet components.
- Focus on natural compounds exhibiting anti-angiogenic effects.
- Analysis of compounds' role in cancer prevention.
Main Results:
- Identified numerous natural compounds in Mediterranean foods with demonstrated anti-angiogenic potential.
- Highlighted the link between these compounds and the angioprevention strategy.
- Emphasized the dietary pattern's significance in cancer chemoprevention.
Conclusions:
- Natural compounds from the Mediterranean diet are promising candidates for angioprevention.
- Dietary strategies incorporating these compounds may reduce cancer incidence and progression.
- Further research into these bioactive compounds can advance cancer prevention efforts.
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Compound Administration II
Molecules and Compounds

