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Updated: Jan 20, 2026
Enteral Nutrition I: Orogastric and Nasogastric Feeding
Published on: May 15, 2025
Complications Associated with Enteral Nutrition: CAFANE Study
Carmina Wanden-Berghe1, Maria-Carmen Patino-Alonso2, Purificación Galindo-Villardón2
1Grupo de Nutrición Clínica y HAD del Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-Fundación FISABIO), Hospital General Universitario de Alicante, 03010 Alicante, Spain. carminaw@telefonica.net.
Choosing the right home enteral nutrition (HEN) method can significantly reduce gastrointestinal complications. Careful selection of formula, route, and administration details is key to minimizing patient risks.
Area of Science:
- Clinical Nutrition
- Gastroenterology
- Patient Care
Background:
- Home enteral nutrition (HEN) is crucial for patients unable to meet nutritional needs orally.
- Understanding the impact of HEN administration modalities on complications is vital for optimizing patient outcomes.
Purpose of the Study:
- To investigate the association between different home enteral nutrition (HEN) administration methods and their associated complications.
- To identify specific HEN modalities that may mitigate or exacerbate adverse events.
Main Methods:
- Prospective, multicenter, longitudinal study across 15 Spanish hospitals (April 2015 - March 2017).
- Included adult patients initiating HEN, with a 4-month follow-up via home visits.
- Evaluated HEN administration type, modality, and complications including gastrointestinal issues, mechanical problems, and bronchoaspiration.
Main Results:
- Specific HEN modalities were associated with reduced risk of constipation and regurgitation.
- Nasogastric tube (NGT) use decreased diarrhea risk but increased tube obstruction risk compared to percutaneous endoscopic gastrostomy (PEG).
- Intermittent gravity feeding reduced risks of vomiting, regurgitation, constipation, diarrhea, and abdominal distension compared to bolus feeding.
Conclusions:
- Gastrointestinal complications are common in HEN patients.
- Optimizing formula, route, feeding modality, dose frequency, administration time, and volume can significantly reduce complication risks.
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