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Updated: Jan 20, 2026

Synthesis of Ligand-free CdS Nanoparticles within a Sulfur Copolymer Matrix
Published on: May 1, 2016
Synthesis of 2-Amino-5-acylthiazoles by a Tertiary Amine-Promoted One-Pot Three-Component Cascade Cyclization Using
Rong-Geng Fu1, Yong Wang1, Fei Xia1
1Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine and TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy , Hunan University of Chinese Medicine , Changsha 410208 , People's Republic of China.
Abstract:
A novel one-pot three-component cascade cyclization strategy for the synthesis of 2-amino-5-acylthiazoles using enaminones, cyanamide, and elemental sulfur has been developed. The reported methods have demonstrated good tolerance of various functional groups. Up to 28 2-amino-5-acylthiazole compounds bearing diverse structural differences were successfully synthesized from easily obtained starting materials with moderate to excellent yields. Our method provides an effective way for the access of valuable and potentially bioactive 2-amino-5-acylthiazole derivatives.
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