Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

12.7K
This protocol describes how to determine whether pharmacological treatments for experimental autoimmune encephalomyelitis show CNS protection as a consequence of suppressing immune cell infiltration or are neuroprotective during the onslaught of immune cell...
12.7K
Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

24.7K
This manuscript describes the methods for induction and scoring of the experimental autoimmune encephalomyelitis (EAE) model, together with the assessment of immune cell distribution and mRNA cytokine levels in lymph nodes, spleen, blood and spinal cord using flow cytometry and quantitative PCR, respectively, at various disease...
24.7K
Following Cell-fate in E. coli After Infection by Phage Lambda06:10

Following Cell-fate in E. coli After Infection by Phage Lambda

24.2K
This article describes the procedure for preparing a fluorescently-labeled version of bacteriophage lambda, infection of E. coli bacteria, following the infection outcome under the microscope, and analysis of infection...
24.2K
The Lambda Select cII Mutation Detection System07:08

The Lambda Select cII Mutation Detection System

8.3K
We describe a detailed protocol for the Lambda Select cII mutation assay in cultured cells of transgenic rodents or the corresponding animals treated with a chemical/physical agent of interest. This approach has been widely used for mutagenicity testing of carcinogens in mammalian...
8.3K
Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α08:26

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

12.5K
Here we present a protocol to describe the development and validation of a single molecule array digital ELISA assay, which enables the ultra-sensitive detection of all IFN-α subtypes in human...
12.5K
Induction of Experimental Autoimmune Hypophysitis in SJL Mice10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

11.9K
This video shows how to induce autoimmune hypophysitis in SJL mice and how to assess its severity by...
11.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyunsaturated fatty acid-derived lipid mediator patterns determine viral pneumonia severity and risk for critical COVID-19.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

In-Treatment Kinetics of Peripheral Blood Immune Markers in PD-L1 High Non-Small Cell Lung Cancer and Prognostic Relevance for Immunotherapy Outcomes.

Cancers·2026
Same author

Proceedings of the 2<sup>nd</sup> Symposium "Autoimmune Diseases -Clinical Unmet Needs in Systemic Autoimmune Diseases Guide Clinical, Translational, and Basic Research".

Mediterranean journal of rheumatology·2026
Same author

Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections.

Cell·2026
Same author

The seven enigmas of SARS-CoV-2: from the past to the future.

Journal of human immunity·2025
Same author

Multiparametric analysis in the peripheral blood of Giant Cell Arteritis and Polymyalgia Rheumatica patients at the early phases of steroid treatment reveals changes in cell subpopulations and lipid mediators: a preliminary study.

Frontiers in immunology·2025

Related Experiment Video

Updated: Jan 20, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.7K

Lambda interferons in immunity and autoimmunity.

Stelios Vlachiotis1, Evangelos Andreakos1

  • 1Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527, Athens, Greece.

Journal of Autoimmunity
|September 5, 2019
PubMed
Summary

Type III interferons (IFNλs) offer antimicrobial defense without inflammation, unlike Type I IFNs. These unique cytokines are crucial for immunity against infections, cancer, and autoimmunity, with potential therapeutic applications.

Keywords:
AutoimmunityCancerImmunityInfectionInflammationLambda interferons

More Related Videos

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

24.7K
Following Cell-fate in E. coli After Infection by Phage Lambda
06:10

Following Cell-fate in E. coli After Infection by Phage Lambda

Published on: October 14, 2011

24.2K

Related Experiment Videos

Last Updated: Jan 20, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.7K
Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

24.7K
Following Cell-fate in E. coli After Infection by Phage Lambda
06:10

Following Cell-fate in E. coli After Infection by Phage Lambda

Published on: October 14, 2011

24.2K

Area of Science:

  • Immunology
  • Virology
  • Autoimmunity

Background:

  • Type I interferons (IFNs) are critical for host defense but can drive autoimmune inflammation.
  • Lambda interferons (IFNλs), or type III IFNs, share similarities with Type I IFNs but have distinct expression patterns and functions.
  • The precise roles of IFNλs in host defense and disease remain incompletely understood.

Purpose of the Study:

  • To review recent advances in understanding IFNλ biology.
  • To highlight the emerging roles of IFNλs in cancer and autoimmune diseases.
  • To discuss the therapeutic potential of IFNλs.

Main Methods:

  • Literature review and critical assessment of recent studies on IFNλ biology.
  • Analysis of data on IFNλ expression and function in various disease models.
  • Synthesis of information regarding the immunoregulatory properties of IFNλs.

Main Results:

  • IFNλs exhibit potent antiviral, antibacterial, and antifungal activities.
  • IFNλs possess non-redundant functions distinct from Type I IFNs.
  • IFNλs act as non-inflammatory or immunoregulatory cytokines, balancing host protection and damage.
  • IFNλs are implicated in immunity against cancer and autoimmunity, with observed upregulation at disease sites.

Conclusions:

  • IFNλs represent a distinct class of interferons with unique immunoregulatory functions.
  • Their non-inflammatory antimicrobial properties make them promising candidates for therapeutic interventions in infectious, autoimmune, and oncological diseases.