Related Experiment Videos
Time dependent pentylenetetrazol-like cues subsequent to diazepam administration
1Veterans Administration Medical Center, Department of Psychology, Nashville, TN.
Psychopharmacology
|January 1, 1988
Summary
Rats injected with diazepam initially pressed the diazepam lever. Over time, they shifted to pressing the pentylenetetrazol lever, showing a drug effect rebound 12 hours post-injection.
Area of Science:
- Pharmacology
- Neuroscience
- Behavioral Science
Background:
- Diazepam and pentylenetetrazol (PTZ) are drugs with distinct effects on behavior.
- Understanding drug-induced behavioral changes is crucial in pharmacology.
Purpose of the Study:
- To investigate the time-dependent behavioral effects of diazepam in rats.
- To examine the potential for a rebound effect or cross-over in drug discrimination.
Main Methods:
- Rats were trained to discriminate between diazepam and pentylenetetrazol injections.
- Dose-response functions were established for both drugs.
- Following diazepam administration, rats were tested at various time intervals (2-24 hours) to assess lever choice.
Main Results:
- At short intervals post-diazepam injection, rats chose the diazepam-associated lever.
- As time progressed, lever choice shifted towards the pentylenetetrazol-associated lever.
- A significant rebound effect, mimicking pentylenetetrazol's effects, was observed around 12 hours post-diazepam, with behavior returning to baseline by 24 hours.
Conclusions:
- Diazepam exhibits time-dependent effects on drug discrimination behavior in rats.
- A notable rebound phenomenon occurs, where diazepam administration can lead to behaviors typically associated with pentylenetetrazol.
- These findings highlight the complex temporal dynamics of drug action on behavior.