Related Experiment Video

Updated: Jan 20, 2026

The Encapsulation of Cell-free Transcription and Translation Machinery in Vesicles for the Construction of Cellular Mimics
10:28

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Published on: October 21, 2013

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DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery

Bandish B Kapadia1, Ronald B Gartenhaus1,2

  • 1University of Maryland School of Medicine, Baltimore, Maryland. rgartenhaus@som.umaryland.edu BKapadia@som.umaryland.edu.

Molecular Cancer Therapeutics
|September 5, 2019
PubMed

Insights

Cancer cells alter protein translation for survival and therapy resistance. This review focuses on deubiquitinating enzymes driving these changes in blood cancers, offering new therapeutic targets.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Cancer cells reprogram gene expression via translation control.
  • Translational control is crucial for tumor adaptation and therapeutic resistance.
  • Dysregulated translation contributes to malignant transformation.

Purpose of the Study:

  • To review the role of deubiquitinating enzymes in cancer translation.
  • To highlight deubiquitinating enzymes dysregulated in hematologic malignancies.
  • To identify therapeutic opportunities targeting oncogenic translation.

Main Methods:

  • Literature review of studies on translation regulation in cancer.
  • Focus on deubiquitinating enzymes and their impact on protein synthesis.
  • Analysis of alterations in hematologic malignancies.

Main Results:

  • Deubiquitinating enzymes are frequently activated or dysregulated in blood cancers.
  • These enzymes reprogram translational output to promote tumorigenesis.
  • Altered translation contributes to cancer cell survival and drug resistance.

Conclusions:

  • Targeting deubiquitinating enzymes offers a promising therapeutic strategy.
  • Understanding oncogenic translation provides novel avenues for cancer treatment.
  • Modulating translational control is key to overcoming therapeutic resistance.

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