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Updated: Jan 20, 2026

Transient Treatment of Human Pluripotent Stem Cells with DMSO to Promote Differentiation
Published on: July 17, 2019
The cell cycle in stem cell proliferation, pluripotency and differentiation
Lijun Liu1,2, Wojciech Michowski2,3, Aleksandra Kolodziejczyk2
1College of Life and Health Sciences, Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China.
Abstract:
Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our current knowledge of how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification. We focus on embryonic stem cells, induced pluripotent stem cells and embryonic neural stem/progenitor cells.
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