Evaluation of Anti-inflammatory Efficacy of RA-V: a Natural Cyclopeptide

Inflammation occurs in a cascade reaction to cause damage in the tissues. It involves increased expression of oxidants and cytokines in the injured tissues. Peptides are chosen for the development of alternate and more selective anti-inflammatory therapies. They are highly specific and significant due to their low molecular weight, simple structure, low antigenicity, and low toxicity. They are capable of easy absorption through different routes of administration and rapid clearance from the system. Plant-derived cyclic peptides have great therapeutic values. Peptides from Rubia cordifolia exhibit potent anti-inflammatory, anti-diabetic, anti-arthritic, and antioxidant properties. Cyclotides are small peptides isolated from plants with a cyclic backbone and disulfide bonds. The cyclic cystine knot structure of the cyclic peptide makes them resistant to chemical, enzymatic, and thermal conditions. They are isolated from Rubiaceae, Violaceae, and Cucurbitaceae plant families. The overall aim of this study is to evaluate the biological efficacy of the cyclopeptide, RA-V (deoxybouvardin) isolated from Rubia cordifolia.