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Related Concept Videos

Weighted Mean00:57

Weighted Mean

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While taking the arithmetic, geometric, or harmonic mean of a sample data set, equal importance is assigned to all the data points. However, all the values may not always be equally important in some data sets. An intrinsic bias might make it more important to give more weightage to specific values over others.
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Mass and Weight01:19

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Mass and weight are often used interchangeably in everyday conversation. For example,  medical records often show our weight in kilograms, but never in the correct units of newtons. In physics, however, there is an important distinction. Weight is the pull of the Earth on an object. It depends on the distance from the center of the Earth. Weight dramatically varies if we leave the Earth's surface, unlike mass, which does not vary with location. On the Moon, for example, the...
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Atomic Weight01:25

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Protons and neutrons have approximately the same mass, about 1.67 × 10-24 grams. Scientists arbitrarily define this amount of mass as one atomic mass unit (amu) or one Dalton. Electrons are much smaller in mass than protons, weighing only 9.11 × 10-28 grams, or about 1/1800 of an atomic mass unit. As a result, they do not contribute much to an element's overall atomic mass. This means that, when considering atomic mass, it is customary to ignore the mass of any electrons and...
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True weight is the measure of the gravitational force acting on an object. However, if the object accelerates, its measured weight is different from its true weight. Similar observations can be made when the object is submerged in water. An object's weight in water is its apparent weight, which is equal to the difference between its true weight and the buoyant forces.
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Cable Subjected to Its Own Weight01:13

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Overhead power transmission lines rely on cables to carry electricity across large distances. To ensure the stability and functionality of these lines, it is crucial to understand the shape and tension experienced by the cables under the influence of their weight.
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Use of a Hanging-weight System for Liver Ischemia in Mice05:53

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We established a novel murine model of a hanging weight system for portal triad occlusion. This technique may be useful for future investigations of ischemia in murine hepatic models.
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Updated: Jan 20, 2026

Use of a Hanging-weight System for Liver Ischemia in Mice
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Published on: August 7, 2012

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U.K. utility weights for the EORTC QLU-C10D.

Richard Norman1, Rebecca Mercieca-Bebber2,3, Donna Rowen4

  • 1School of Public Health, Curtin University, Perth, Western Australia, Australia.

Health Economics
|September 5, 2019
PubMed
Summary
This summary is machine-generated.

This study established United Kingdom general population utility weights for the EORTC QLU-C10D, a cancer quality of life tool. These weights are crucial for cost-utility analyses of new cancer treatments in the UK.

Keywords:
cancerdiscrete choice experimenthealth state valuationutility

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Area of Science:

  • Health Economics
  • Psychometrics
  • Oncology

Background:

  • The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) is widely used for cancer quality of life assessment.
  • The EORTC QLU-C10D is a new multi-attribute utility instrument derived from the EORTC QLQ-C30, comprising 10 dimensions.
  • Utility weights are essential for cost-utility analyses (CUA) to evaluate healthcare interventions.

Purpose of the Study:

  • To derive United Kingdom general population utility weights for the EORTC QLU-C10D.
  • To facilitate economic evaluations of new oncology therapies and technologies in the UK.

Main Methods:

  • A quota-sampled UK online panel (n=2,187) participated in an online valuation survey.
  • A discrete choice experiment (DCE) was employed, with participants completing 16 choice-pairs of QLU-C10D health states.
  • Conditional logistic regression was used to analyze DCE data and generate utility weights.

Main Results:

  • Utility weights for the UK general population for the EORTC QLU-C10D were successfully generated.
  • A monotonic relationship between health state severity and utility was observed for most dimensions, with adjustments made for appetite.
  • The largest utility decrements were associated with physical functioning and pain. The worst health state utility was -0.083.

Conclusions:

  • The derived UK-specific QLU-C10D utility weights will enable robust cost-utility analyses for oncology interventions.
  • These weights support informed resource allocation decisions in UK healthcare for cancer treatments.
  • The study provides a valuable tool for assessing the economic value of new cancer therapies.