Reduced lung elastic recoil and fixed airflow obstruction in asthma

Fixed airflow obstruction (FAO) in asthma occurs despite optimal inhaled treatment and no smoking history, and remains a significant problem, particularly with increasing age and duration of asthma. Increased lung compliance and loss of lung elastic recoil has been observed in older people with asthma, but their link to FAO has not been established. We determined the relationship between abnormal lung elasticity and airflow obstruction in asthma.

Non-smoking asthmatic subjects aged >40 years, treated with 2 months of high-dose inhaled corticosteroid/long-acting beta-agonist (ICS/LABA), had FAO measured by spirometry, and respiratory system resistance at 5 Hz (Rrs₅ ) and respiratory system reactance at 5 Hz (Xrs₅ ) measured by forced oscillation technique. Lung compliance (K) and elastic recoil (B/A) were calculated from pressure-volume curves measured by an oesophageal balloon. Linear correlations between K and B/A, and forced expiratory volume in 1 s/forced vital capacity (FEV₁ /FVC), Rrs₅ and Xrs₅ were assessed.

Eighteen subjects (11 males; mean ± SD age: 64 ± 8 years, asthma duration: 39 ± 22 years) had moderate FAO measured by spirometry ((mean ± SD z-score) post-bronchodilator FEV₁ : -2.2 ± 0.5, FVC: -0.7 ± 1.0, FEV₁ /FVC: -2.6 ± 0.7) and by increased Rrs₅ (median (IQR) z-score) 2.7 (1.9 to 3.2) and decreased Xrs₅ : -4.1(-2.4 to -7.3). Lung compliance (K) was increased in 9 of 18 subjects and lung elastic recoil (B/A) reduced in 5 of 18 subjects. FEV₁ /FVC correlated negatively with K (r_s = -0.60, P = 0.008) and Rrs₅ correlated negatively with B/A (r_s = -0.52, P = 0.026), independent of age. Xrs₅ did not correlate with lung elasticity indices.

Increased lung compliance and loss of elastic recoil relate to airflow obstruction in older non-smoking asthmatic subjects, independent of ageing. Thus, structural lung tissue changes may contribute to persistent, steroid-resistant airflow obstruction.

ACTRN126150000985583 at anzctr.org.au (UTN: U1111-1156-2795).