Keeping up with the clinical advances: tardive dyskinesia

This article describes methods to induce and evaluate levodopa-induced dyskinesias in a rat model of Parkinson's disease. The protocol offers detailed information regarding the intensity and frequency of a range of dyskinetic behaviors, both dystonic and hyperkinetic, providing a reliable tool to test treatments targeting this unmet medical...

Handwriting analysis software significantly improves upon existing instruments measuring movement disorders. Individuals at risk for psychosis and healthy controls completed handwriting tasks to test for dyskinesia. Results suggest that youth at risk for psychosis exhibit dyskinesia and that handwriting analysis could significantly contribute to wider dissemination of early identification...

This video demonstrates the process of inducing levodopa-induced dyskinesias in a Parkinson's rat model by administering levodopa alongside a dopamine conversion inhibitor. Repeated injections overstimulate the brain neurons, resulting in motor...

Organic Lab Notebook Keeping
Record keeping is a vital skill in science and organic chemistry labs. Without proper notes, descriptions, quantities, or observations, an experiment conducted in the lab cannot be replicated or reproduced. Therefore, keeping an accurate and up-to-date notebook is necessary to achieve reproducibility in science. A laboratory notebook is a powerful tool in both academic and industrial settings. It becomes especially important when a discovery is patented and...

Source: Lara Al Hariri and Ahmed Basabrain at the University of Massachusetts Amherst, MA, USA

Source: Lara Al Hariri at the University of Massachusetts Amherst, MA, USA