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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
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Multidrug resistant tumors-aimed theranostics on the basis of strong electrostatic attraction between resistant cells

Shuwei Liu1, Lu Wang2, Shuyao Li1

  • 1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China. hao_zhang@jlu.edu.cn.

Biomaterials Science
|September 5, 2019
PubMed

Insights

Multidrug-resistant tumor cells attract nanomaterials due to increased negative charge. This enables targeted theranostics, combining imaging, chemotherapy, and photothermal therapy for improved cancer treatment efficacy.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Chemotherapy resistance in tumors is a significant clinical challenge.
  • Resistant tumor cells exhibit increased sialic acid and negative membrane potential.
  • This altered cell surface presents a unique target for novel theranostic strategies.

Purpose of the Study:

  • To develop and evaluate a nanomaterial-based theranostic approach for multidrug-resistant tumors.
  • To leverage the electrostatic attraction between positively charged nanomaterials and negatively charged resistant tumor cells.
  • To investigate the combined efficacy of chemotherapy, magnetic resonance imaging, and photothermal therapy.

Main Methods:

  • Synthesized polyethylene glycol-coated, Cu(II) and vincristine co-doped polyaniline nanoshuttles (VCR-PEG-CuPani NSs).
  • Utilized human oral epithelial carcinoma vincristine-resistant (KBV) and sensitive (KB) tumor models.
  • Assessed nanomaterial accumulation via electrostatic attraction and evaluated theranostic performance in vivo.

Main Results:

  • VCR-PEG-CuPani NSs demonstrated enhanced accumulation in KBV tumors (8.05 ± 0.39% ID g⁻¹) compared to KB tumors (6.02 ± 0.22% ID g⁻¹).
  • The nanoshuttles exhibited a favorable blood circulation half-life of 6.26 ± 0.16 hours.
  • Improved theranostic outcomes were observed, including enhanced chemotherapy, MRI, and photothermal therapy efficacy in resistant tumors.

Conclusions:

  • Positively charged VCR-PEG-CuPani NSs effectively target multidrug-resistant tumors via electrostatic attraction.
  • This targeted approach enhances the efficacy of combined imaging, chemotherapy, and photothermal therapy.
  • The developed theranostic model offers a promising strategy for overcoming chemotherapy resistance in cancer treatment.

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