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Updated: Jan 20, 2026

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions
Published on: June 6, 2025
Salt Preference is Linked to Hypertension and not to Aging
Patrícia Teixeira Meirelles Villela1, Eduardo Borges de-Oliveira1, Paula Teixeira Meirelles Villela1
1Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo (FMRP-USP) - Divisão de Clínica Médica Geral e Geriatria, Ribeirão Preto, SP - Brazil.
Hypertensive individuals prefer saltier foods, but seasoning bread reduced their preference for salt. Seasoning can help reduce salt intake in both hypertensive and normotensive individuals, regardless of age.
Area of Science:
- Nutrition Science
- Cardiovascular Health
- Dietary Habits
Background:
- Reducing dietary salt intake is crucial for managing hypertension.
- Seasoning is a potential strategy to decrease salt consumption.
- Limited research exists on how seasoning affects salt preference.
Purpose of the Study:
- To compare salt preference in bread among hypertensive and normotensive outpatients.
- To investigate if seasoning can alter salt preference in these groups.
- To assess the influence of age on salt preference in relation to hypertension.
Main Methods:
- 118 outpatients were divided into four groups: young/older hypertensive and young/older normotensive.
- Participants tasted bread samples with varying salt concentrations before and after seasoning.
- Blood pressure and urinary sodium/potassium excretion were measured.
Main Results:
- Hypertensive individuals showed a higher preference for saltier bread compared to normotensive individuals.
- Seasoning significantly reduced the preference for saltier bread in all groups, especially hypertensive individuals.
- Age did not significantly influence salt preference, but hypertension did.
Conclusions:
- Hypertension, not age, is linked to a higher preference for salt.
- Seasoned bread effectively reduced salt preference across all participant groups.
- Seasoning is a viable strategy to encourage lower salt consumption in diverse populations.
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