Related Experiment Video
Updated: Jan 20, 2026

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
Published on: March 13, 2018
[A patient with unexplained neurological symptoms]
Ester S Maris-Boes1,2, Anneke A J Ramdhani-Joosten3, Anne Neeltje Scholte-Stalenhoef1
1ZiekenhuisGroep Twente, afd. Psychiatrie, Almelo.
In this case of a 54-year-old woman, severe impairment of motor and sensory function - that could not be assigned to any neurological disease - was diagnosed as a probable conversion disorder or functional neurological disorder (FND). Several psychological stressors, which occurred in the year that preceded the first development of symptoms, were linked to the disorder. Nerve conduction values had not shown any abnormalities at the onset of the disease. However, as the condition progressed, cerebrospinal fluid and nerve conduction study proved an underlying polyneuropathy. In this article we discuss the diagnostic process followed in this case. General lack of evidence for psychological conflict being related to symptoms of conversion disorder/FND led to elimination of this criterion in DSM 5. Instead, the diagnostic process of conversion disorder/FND requires not only exclusion of neurological causes for the symptoms, but also active examination of neurological findings that are discrepant with known neurological diseases; taken together this can positively support a diagnosis of conversion disorder/FND.
In this case of a 54-year-old woman, severe impairment of motor and sensory function - that could not be assigned to any neurological disease - was diagnosed as a probable conversion disorder or functional neurological disorder (FND). Several psychological stressors, which occurred in the year that preceded the first development of symptoms, were linked to the disorder. Nerve conduction values had not shown any abnormalities at the onset of the disease. However, as the condition progressed, cerebrospinal fluid and nerve conduction study proved an underlying polyneuropathy. In this article we discuss the diagnostic process followed in this case. General lack of evidence for psychological conflict being related to symptoms of conversion disorder/FND led to elimination of this criterion in DSM 5. Instead, the diagnostic process of conversion disorder/FND requires not only exclusion of neurological causes for the symptoms, but also active examination of neurological findings that are discrepant with known neurological diseases; taken together this can positively support a diagnosis of conversion disorder/FND.
Related Concept Videos
06:12Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
04:33Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
08:47Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
06:49A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
10:25Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
08:11Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

