[A patient with unexplained neurological symptoms]

Ester S Maris-Boes1,2, Anneke A J Ramdhani-Joosten3, Anne Neeltje Scholte-Stalenhoef1

  • 1ZiekenhuisGroep Twente, afd. Psychiatrie, Almelo.

In this case of a 54-year-old woman, severe impairment of motor and sensory function - that could not be assigned to any neurological disease - was diagnosed as a probable conversion disorder or functional neurological disorder (FND). Several psychological stressors, which occurred in the year that preceded the first development of symptoms, were linked to the disorder. Nerve conduction values had not shown any abnormalities at the onset of the disease. However, as the condition progressed, cerebrospinal fluid and nerve conduction study proved an underlying polyneuropathy. In this article we discuss the diagnostic process followed in this case. General lack of evidence for psychological conflict being related to symptoms of conversion disorder/FND led to elimination of this criterion in DSM 5. Instead, the diagnostic process of conversion disorder/FND requires not only exclusion of neurological causes for the symptoms, but also active examination of neurological findings that are discrepant with known neurological diseases; taken together this can positively support a diagnosis of conversion disorder/FND.

Related Concept Videos

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram06:12

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

The article describes a practical method for recording horizontal eye movements with high accuracy by electro-oculogram in neurological patients, using a cup Ag-AgCl electrode with a wide plastic fringe. Stable measurement requires proper selection and fixation of electrodes, taking sufficient time for light adaptation to occur, and re-calibration as...
11.1K
Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Here, we present a protocol that investigates the relationship between cognitive symptoms and sleep quality in patients with major depressive disorder. The THINC-integrated tool and polysomnography were used to evaluate cognitive symptoms and sleep...
1.2K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

A protocol for conducting a challenge in an allergen exposure chamber (AEC) facility is presented. AECs have proven to be safe and effective tools for the induction of allergic symptoms or as an endpoint in the efficacy testing of allergen immunotherapy due to their ability to maintain stable particle concentrations and environmental...
2.9K
A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

This video protocol describes a sensitive, reliable, and quick method for evaluating the neuromuscular deficits in a transgenic mouse model of amyotrophic lateral...
20.8K
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Provided here is a practical tutorial for an open-access, standardized image processing pipeline for the purpose of lesion-symptom mapping. A step-by-step walkthrough is provided for each processing step, from manual infarct segmentation on CT/MRI to subsequent registration to standard space, along with practical recommendations and illustrations with exemplary...
49.3K
Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis08:11

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

An optimized testing protocol is presented in this paper for the Rotarod performance test, used for measuring progressive neurological disability in TMEV-infected mice.
11.5K