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Related Concept Videos

Silicon Microchips for Manipulating Cell-cell Interaction23:21

Silicon Microchips for Manipulating Cell-cell Interaction

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This article describes an experimental approach for dynamic regulation of cell-cell interactions between adherent cells on a micrometer scale. Manipulation of intercellular communication between hepatocytes and stromal cell is demonstrated. The developed platform enables investigation of cell-cell interactions in a variety of biological processes, including development and...
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Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation16:27

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We present two independent, microscope-based tools to measure the induced nuclear and cytoskeletal deformations in single, living adherent cells in response to global or localized strain application. These techniques are used to determine nuclear stiffness (i.e., deformability) and to probe intracellular force transmission between the nucleus and the...
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Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells07:55

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An integrated cell manipulation platform is developed for use in conjunction with a single-probe mass spectrometry setup for the on-line analysis of individual suspension cells under ambient...
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Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions14:43

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An Introduction to Cell Motility and Migration08:52

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Related Experiment Video

Updated: Jan 20, 2026

Silicon Microchips for Manipulating Cell-cell Interaction
23:21

Silicon Microchips for Manipulating Cell-cell Interaction

Published on: August 30, 2007

11.1K

Combined Single-Cell Manipulation and Chemomechanical Modeling to Probe Cell Migration Mechanism During Cell-to-Cell

Xue Gou, J C E, Hao Yang

    IEEE Transactions on Bio-Medical Engineering
    |September 5, 2019
    PubMed
    Summary

    This study introduces a chemomechanical model to understand how chemical and mechanical cues influence single cell migration during cell-to-cell interactions. Findings reveal dynamic adhesion forces can alter chemotaxis, impacting cancer cell movement and drug treatment efficacy.

    More Related Videos

    Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
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    Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells
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    Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

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    Related Experiment Videos

    Last Updated: Jan 20, 2026

    Silicon Microchips for Manipulating Cell-cell Interaction
    23:21

    Silicon Microchips for Manipulating Cell-cell Interaction

    Published on: August 30, 2007

    11.1K
    Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
    16:27

    Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

    Published on: September 14, 2011

    12.9K
    Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells
    07:55

    Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

    Published on: June 21, 2019

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    Area of Science:

    • Cell Biology
    • Biophysics
    • Computational Biology

    Background:

    • Cell migration is crucial for biological processes, influenced by chemical and mechanical signals.
    • Existing models often overlook synergistic effects in single-cell migration during cell-to-cell interactions.

    Purpose of the Study:

    • To develop a chemomechanical model for analyzing biochemical and biophysical modulators of single cell migration during cell-to-cell interactions.
    • To investigate the interplay between chemoattractant gradients, dynamic adhesion, and cell-cell motion.

    Main Methods:

    • Development of a novel chemomechanical model incorporating chemoattractant gradients, dynamic adhesion strength, and relative cell motion.
    • Validation using optical tweezers to manipulate leukemia cancer cells on a stromal cell layer.

    Main Results:

    • Cell migration velocity influenced by chemotaxis is significantly modulated by dynamic adhesion forces, linked to stromal cell retrograde flow.
    • Biophysical modulators impact the effectiveness of drug treatments targeting specific cell signaling pathways.

    Conclusions:

    • The model provides a quantitative framework for understanding single cell migration in complex, in vivo-like environments.
    • This research offers insights into cell signaling pathways during cell-cell interactions for potential therapeutic strategies.