Related Experiment Video
Updated: Jan 20, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Deprescribing: Practical Ways to Support Person-Centred, Evidence-Based Deprescribing
Katherine Le Bosquet1, Nina Barnett2, John Minshull2
1Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK. Katherine.lebosquet@nhs.net.
Abstract:
Deprescribing is complex and multifactorial with multiple approaches described in the literature. Internationally, there are guidelines and tools available to aid clinicians and patients to identify and safely withdraw inappropriate medications, post a shared decision-making medicines optimisation review. The increase in available treatments and use of single disease model guidelines have led to a healthcare system geared towards prescribing, with deprescribing often seen as a separate activity. Deprescribing should be seen as part of prescribing, and is a key element in ensuring patients remain on the most appropriate medications at the correct doses for them. Due to the complex nature of polypharmacy, every patient experience and relationship with medications is unique. The individual's history must be incorporated into a patient-centred medication review, in order for medicines to remain optimal through changes in circumstance and health. Knowledge of the law and appropriate recording is important to ensure consent is adequately gained and recorded in line with processes followed when initiating a medication. In recent years, with the increase in interested clinicians globally, a number of prominent networks have grown, creating crucial links for both research and sharing of good practice.
Related Concept Videos
The Evidence for Evolution
05:47Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
19:56Introduction to Solid Supported Membrane Based Electrophysiology
Self-Help Support Groups
Accessibility and Cost-Effectiveness
One of the primary strengths of self-help...
The 4 M’s Framework: Case History and Physical Examination of Older Adults
To meet the needs of older adults, all health professionals should be well acquainted with the history and physical examination considerations unique to this population. Physical examination plays an important role in the older patient to detect physiologic changes of aging, risk factors, and signs of pathology. While most of the general principles of the standard examination for adults apply to older patients,...
07:21Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
