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Related Concept Videos

Gallbladder01:17

Gallbladder

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The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy10:51

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We describe the protocols used to investigate the interactions of 13.56 MHz radiofrequency (RF) electric-fields with gold nanoparticle colloids in both non-biological and biological systems (in vitro/vivo). These interactions are being investigated for applications in cancer...
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Use of Cerenkov Luminescence Imaging (CLI) for monitoring preclinical cancer treatment is described here. This method takes advantage of Cerenkov Radiation (CR) and optical imaging (OI) to visualize radiolabeled probes and thus provides an alternative to PET in preclinical therapeutic monitoring and drug...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Updated: Jan 20, 2026

Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy
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Systemic therapy for gallbladder cancer.

Milind Javle1, Haitao Zhao2, Ghassan K Abou-Alfa3,4

  • 1Department of Gastrointestinal Oncology, MD Anderson Cancer Center, Houston, TX, USA. mjavle@mdanderson.org.

Chinese Clinical Oncology
|September 6, 2019
PubMed
Summary
This summary is machine-generated.

Gallbladder cancer, often diagnosed late, shares treatments with biliary tract cancer. Molecular profiling reveals distinct genetic targets, offering new hope for targeted therapies in gallbladder cancer treatment.

Keywords:
Cancer of gallbladdergenes ErbB2targeted therapy

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Gallbladder
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Area of Science:

  • Oncology
  • Gastroenterology
  • Genetics

Background:

  • Gallbladder cancer is an aggressive malignancy with significant healthcare implications, particularly in Southeast Asia and Latin America.
  • Most patients present with advanced, unresectable disease, necessitating systemic therapy.
  • Current treatment strategies for gallbladder cancer are often extrapolated from biliary tract cancer trials.

Purpose of the Study:

  • To review current systemic therapy options for gallbladder cancer.
  • To highlight the importance of molecular profiling in identifying unique therapeutic targets.
  • To discuss the potential of targeted therapies based on genetic aberrations.

Main Methods:

  • Review of current chemotherapy regimens used in clinical trials for biliary tract cancer, including gallbladder cancer.
  • Analysis of molecular profiling data differentiating gallbladder cancer from cholangiocarcinoma.
  • Identification of actionable genetic targets such as Her2/neu amplification, PIK3CA mutations, and DNA repair aberrations.

Main Results:

  • Standard first-line chemotherapy includes gemcitabine and cisplatin; second-line treatment often involves FOLFOX.
  • Molecular profiling reveals distinct genetic landscapes between gallbladder cancer and cholangiocarcinoma.
  • Key actionable targets identified include Her2/neu amplification, PIK3CA mutations, and DNA repair genetic aberrations.

Conclusions:

  • Systemic chemotherapy for gallbladder cancer mirrors that of cholangiocarcinoma, but ongoing trials may alter this paradigm.
  • Genetic differences necessitate tailored targeted therapy approaches for gallbladder cancer.
  • Targeting specific molecular alterations like Her2/neu amplification and PIK3CA mutations holds promise for improved patient outcomes.