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Related Experiment Video

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Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety.

Kelly M Ness1,2,3, Stephen M Strayer1,2, Nicole G Nahmod2

  • 1Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802.

Journal of Lipid Research
|September 6, 2019
PubMed
Summary
This summary is machine-generated.

Chronic sleep restriction impairs the body's ability to process fats after a high-fat meal. While one night of recovery sleep restored triglyceride metabolism, it did not fully recover markers of adipocyte function.

Keywords:
diet and dietary lipidsfatty acidglucosehormonesinflammationinsulin resistancelipolysis and fatty acid metabolismnutritiontriglycerides

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Area of Science:

  • Metabolic Physiology
  • Sleep Science

Background:

  • Chronic sleep restriction is linked to cardiometabolic disease risk.
  • Inadequate sleep impairs whole-body insulin sensitivity and glucose disposal.
  • Previous research suggests impaired adipose tissue insulin sensitivity with inadequate sleep.

Purpose of the Study:

  • To investigate the impact of sleep restriction on postprandial lipemia after a high-fat meal.
  • To determine if one night of recovery sleep can restore postprandial metabolism.

Main Methods:

  • Four nights of 5 hours time in bed (TIB) restricted sleep.
  • Standardized high-fat dinner challenge.
  • Measurement of postprandial triglycerides, non-esterified fatty acids (NEFAs), and interleukin-6.
  • Assessment of satiety and one night of 10 hours TIB recovery sleep.

Main Results:

  • Sleep restriction suppressed postprandial triglyceride (TG) area under the curve (P=0.01).
  • Non-esterified fatty acids (NEFAs) were decreased throughout the high-fat meal challenge during sleep restriction (P=0.02) and remained suppressed post-recovery (P=0.04).
  • Sleep restriction reduced satiety (P=0.03) and postprandial interleukin-6 (P<0.01).

Conclusions:

  • Four nights of sleep restriction (5h TIB) negatively impacts postprandial lipemia.
  • One night of recovery sleep (10h TIB) may be sufficient to restore TG metabolism but not adipocyte function markers.
  • Sleep restriction affects satiety and inflammatory markers post-meal.