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Cholinergic urticaria, passive transfer experiments from human to monkey.

G M Murphy1, M W Greaves, P E Zollman

  • 1St John's Hospital for Diseases of the Skin, London, UK.

Dermatologica
|January 1, 1988
PubMed
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Researchers found a serum factor in cholinergic urticaria that increases vascular permeability when combined with acetylcholine. This discovery offers new insights into the mechanisms of this histamine-independent urticaria.

Area of Science:

  • Dermatology
  • Immunology
  • Allergy

Background:

  • Cholinergic urticaria is a histamine-independent physical urticaria.
  • Its exact pathogenesis remains unclear, particularly the role of serum factors.

Purpose of the Study:

  • To investigate the potential role of a serum factor in mediating the vascular response in cholinergic urticaria.

Main Methods:

  • Passive transfer of serum from 16 cholinergic urticaria patients to a Macaca cymologous monkey.
  • Assessment of vascular permeability using intravenous Evans blue dye.
  • Challenge with localized heat and acetylcholine administration at serum-injected and control sites.

Main Results:

  • Local heat challenge did not induce a response.

Related Experiment Videos

  • Seven out of 16 serum-injected sites reacted positively to acetylcholine challenge.
  • Control injections of acetylcholine into non-serum-injected sites did not elicit a response.

    • Conclusions:

    • A serum factor present in patients with cholinergic urticaria appears to mediate increased vascular permeability in response to acetylcholine.
    • This factor, in conjunction with acetylcholine, plays a role in the pathophysiology of cholinergic urticaria.