Non-Thermal Plasma-Induced Immunogenic Cell Death in Cancer: A Topical Review.

Area of Science:

• Biomedical Research
• Cancer Immunotherapy
• Plasma Medicine

Background:

• Oxidative stress-based approaches are emerging in cancer immunotherapy.
• These methods aim to induce immunogenic cell death (ICD) in cancer cells.
• Non-thermal plasma (NTP) generates reactive oxygen and nitrogen species, suggesting its potential for ICD induction.

Purpose of the Study:

• To review recent investigations on the application of NTP for inducing ICD in cancer cells.
• To explore the potential of NTP as a modality for cancer immunotherapy.

Main Methods:

• Review of recent scientific literature on NTP and cancer treatment.
• Analysis of studies investigating NTP's effects on cancer cells and immune responses.

Main Results:

• NTP treatment rapidly destroys cancer cells.
• Specific NTP regimens can lead to systemic tumor-specific immunity.
• NTP enhances interactions between tumor cells and local immune cells, initiating protective immune responses.

Conclusions:

• NTP is a promising modality for inducing immunogenic cell death in cancer.
• Further optimization of NTP devices and protocols could establish it as a key component of cancer therapeutic strategies.