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Updated: Jan 20, 2026
01:18
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
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Andexanet Alfa (Andexxa®) for the Reversal of Direct Oral Anticoagulants
P & T : a Peer-Reviewed Journal for Formulary Management
|September 6, 2019
Abstract:
Andexanet alfa (Andexxa®) for the reversal of direct oral anticoagulants.
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Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
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Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
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