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Updated: Jan 20, 2026
A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Theoretical Modeling of Long-Time Drug Release from Nitrosalicyl-Imine-Chitosan Hydrogels through Multifractal
Anda-Mihaela Craciun1, Mihaela Luminita Barhalescu2, Maricel Agop3,4
1Petru Poni Institute of Macromolecular Chemistry, GrigoreGhicaVoda Alley, Iasi, Romania.
Abstract:
Drug release is a complex phenomenon due to the large number of interdependent side effects that occur simultaneously, involving strong nonlinear dynamics. Therefore, since their theoretical description is difficult in the classical mathematics modelling, we have built a theoretical model based on logistic type laws, validated by the correlations with the experimental data, in a special case of drug release from hydrogels. The novelty of our approach is the implementation of multifractality in logistic type laws, situation in which any chaotic system, characterized by a small number of nonlinear interactions, gets memory and, implicitly, characterization through a large number of nonlinear interactions. In other words, the complex system polymer-drug matrix becomes "pseudo-intelligent."
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