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Updated: Jan 20, 2026
01:28
Gene Regulation in Microbial Communities: Quorum Sensing
Published on: June 12, 2025
537
Complementary-sense gene regulation in beet curly top virus-SpCT
Jennifer Guerrero1, Garry Sunter2
1Department of Biology, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Archives of Virology
|September 6, 2019
Summary
Beet curly top virus (BCTV-SpCT) and related viruses share gene regulation strategies. A specific DNA region and the C1 protein are crucial for activating BCTV-SpCT
Area of Science:
- Plant virology
- Molecular biology
- Genetics
Background:
- Beet curly top virus (BCTV-SpCT) is a plant pathogen.
- Curtoviruses and begomoviruses are related virus families.
Purpose of the Study:
- To investigate the regulatory mechanisms of BCTV-SpCT C2/C3 gene expression.
- To compare gene regulation strategies between BCTV-SpCT and other geminiviruses.
Main Methods:
- Sequence analysis of the BCTV-SpCT promoter region.
- Mutational analysis of the BCTV-SpCT C1 gene initiator codon.
Main Results:
- A 278-bp upstream region of BCTV-SpCT C2/C3 genes is essential for promoter activity.
- This region shows similarity to tomato golden mosaic virus (TGMV) AL2/3 promoter sequences.
- BCTV-SpCT C1 protein is required for maximal C2/C3 gene expression.
- Mutating the C1 initiator codon reduced C2/C3 expression.
Conclusions:
- BCTV-SpCT, TGMV, and cabbage leaf curl virus share a common gene regulation strategy.
- This suggests a conserved mechanism for complementary-sense gene regulation in curtoviruses and begomoviruses.
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