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Articles linked to this work by shared authors, journal, and citation graph.

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Altered resting-state functional connectivity of default mode network in brachioradial pruritus.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
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[Evaluation of outpatient medical pain management in Germany : Results of an internet-based cross-sectional survey among pain specialists in outpatient departments].

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[Pruritus medicine-interdisciplinary exchange].

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[Recommendations for the perioperative use of dipyrone : Expert recommendation of the working group on acute pain of the German Pain Society, the scientific working group on pain medicine of the German Society for Anesthesiology and Intensive Care Medicine and the surgical working group on acute pain of the German Society for Surgery with participation of representatives of the Drug Commission of the German Medical Association].

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[Recommendations for the perioperative use of dipyrone : Expert recommendation of the working group on acute pain of the German Pain Society, the scientific working group on pain medicine of the German Society for Anesthesiology and Intensive Care Medicine and the surgical working group on acute pain of the German Society for Surgery with participation of representatives of the Drug Commission of the German Medical Association].

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[Erythromelalgia: skin redness and pain].

M Dusch1, M Schmelz2

  • 1Klinik für Anästhesiologie und Intensivmedizin, Fachbereich Schmerzmedizin, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland. dusch.martin@mh-hannover.de.

Schmerz (Berlin, Germany)
|September 6, 2019
PubMed
Summary

Erythromelalgia is a rare condition causing burning pain and redness in extremities, often triggered by heat. Diagnosis is clinical, confirmed by genetic testing for sodium channel NaV1.7 mutations.

Keywords:
Combined modality therapyComplex regional pain syndromeNaV1.7 voltage-gated sodium channelNeuropathic painNon-freezing cold injury

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Area of Science:

  • Neurology
  • Genetics
  • Dermatology

Background:

  • Erythromelalgia is a rare disorder.
  • It can be associated with hemato-oncological diseases, toxins, or occur independently due to genetic mutations.
  • Mutations in the sodium channel NaV1.7 are a known cause.

Purpose of the Study:

  • To describe the clinical presentation, diagnosis, and management of Erythromelalgia.
  • To highlight the role of NaV1.7 gene mutations.
  • To differentiate Erythromelalgia from other conditions.

Main Methods:

  • Clinical diagnosis based on characteristic symptoms.
  • Genetic testing for NaV1.7 mutations.
  • Differential diagnosis evaluation.

Main Results:

  • Erythromelalgia presents with burning pain, redness, and relief with cooling.
  • Attacks are triggered by heat, exertion, and stress.
  • Genetic testing can confirm NaV1.7 channelopathy.

Conclusions:

  • Erythromelalgia requires a multidisciplinary therapeutic approach.
  • Treatment should be individualized, including physical therapy, psychotherapy, and pharmacotherapy.
  • Distinguishing from complex regional pain syndrome and small fiber neuropathies is crucial.