Related Experiment Video

Updated: Jan 20, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

10.8K

Atroposelective Total Synthesis of the Fourfold ortho-Substituted Naphthyltetrahydroisoquinoline Biaryl

Eric D Slack1, Raina Seupel2, Donald H Aue1

  • 1Department of Chemistry & Biochemistry, University of California, Santa Barbara, 93106, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|September 6, 2019
PubMed

Keywords:
Negishi couplingPd catalysisatropisomerismbifurcationdensity functional calculationsligand design

More Related Videos

Nucleophilic Substitution: SN1 and SN2 Reactions14:21

Nucleophilic Substitution: SN1 and SN2 Reactions

Published on: April 30, 2023

102.7K
Synthesis, Crosslinking and Characterization of Hydrogels08:33

Synthesis, Crosslinking and Characterization of Hydrogels

Published on: April 30, 2023

25.0K

Related Concept Videos

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

An operationally simple procedure for the synthesis of ortho-trifluoromethoxylated aniline derivatives via a two-step sequence of O-trifluoromethylation of N-aryl-N-hydroxyacetamide followed by thermally induced intramolecular OCF3-migration is...
10.8K
Nucleophilic Substitution14:21

Nucleophilic Substitution

Source: Vy M. Dong and Daniel Kim, Department of Chemistry, University of California, Irvine, CA
Nucleophilic substitution reactions are among the most fundamental topics covered in organic chemistry. A nucleophilic substitution reaction is one where a nucleophile (electron-rich Lewis base) replaces a leaving group from a carbon atom.
SN1 (S = Substitution, N = Nucleophilic, 1 = first-order kinetics)
SN2 (S = Substitution, N = Nucleophilic, 2 = second-order kinetics)
This video will help to...
102.7K
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction01:26

Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction

α-Substituted ketones or aldehydes can be synthesized from enamines by the Stork enamine reaction, named after its pioneer Gilbert Stork. Enamines are useful synthetic intermediates where the lone pair on nitrogen is in conjugation with the C=C bond. They resemble enolate ions, as the resonance forms of both species have a nucleophilic α carbon.
4.1K
Directing Effect of Substituents: ortho–para-Directing Groups01:14

Directing Effect of Substituents: ortho–para-Directing Groups

Ortho–para directors are substituent groups attached to the benzene ring and direct the addition of an electrophile to the positions ortho or para to the substituent. All electron-donating groups are considered ortho–para directors. They donate electrons to the ring and make the ring more electron-rich. The ring is therefore susceptible to the addition of electrophiles. Substituents such as amino, hydroxy, or alkoxy, containing lone pairs on the atom adjacent to the ring, donate...
8.3K
Hydrogel Synthesis08:33

Hydrogel Synthesis

Source: Amber N. Barron, Ashlea Patterson, and Taylor D. Sparks, Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT
Hydrogels are a versatile class of cross-linked polymers produced through relatively simple procedures and with generally inexpensive materials. They can be formed from solution and involve a polymer backbone formed from monomer reagents, an initiator which makes the polymer reactive and a crosslinking species which binds the polymer chains...
25.0K
Object Substitution Masking10:14

Object Substitution Masking

Source: Laboratory of Jonathan Flombaum—Johns Hopkins University
Visual masking is a term used by perceptual scientists to refer to a wide range of phenomena in which in an image is presented but not perceived by an observer because of the presentation of a second image. There are several different kinds of masking, many of them relatively intuitive and unsurprising. But one surprising and important type of masking is called Object Substitution Masking. It has been a focus of research in...
7.0K