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Recent Advances in 4D Bioprinting.

Qingzhen Yang1,2, Bin Gao3, Feng Xu1,2

  • 1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.

Biotechnology Journal
|September 6, 2019
PubMed
Summary
This summary is machine-generated.

4D bioprinting integrates time into 3D bioprinting, allowing constructs to change shape and function. This review covers recent advances in materials, control methods, and biomedical applications of this transformative technology.

Keywords:
biofabricationprintingresponsive materialsself-foldingsmart materials

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Materials Science

Background:

  • 4D bioprinting builds upon 3D bioprinting by incorporating the dimension of time.
  • This allows for the creation of dynamic bioconstructs that can alter their shape or function in response to stimuli.
  • It enables the fabrication of complex structures not achievable with traditional 3D printing.

Purpose of the Study:

  • To review recent advances in 4D bioprinting technology.
  • To discuss the underlying mechanisms, design principles, and biomedical applications.
  • To highlight current challenges and future directions in the field.

Main Methods:

  • Development of novel 4D printable materials.
  • Exploration of precise process control methods.
  • Investigation of biomedical engineering applications.

Main Results:

  • Bioconstructs with spatiotemporal control over shape and functionality have been successfully printed.
  • Complex structures that dynamically respond to stimuli have been achieved.
  • Progress has been made in developing new materials and control strategies.

Conclusions:

  • 4D bioprinting is a rapidly advancing field with significant potential in biomedical engineering.
  • Further research into materials, process control, and applications is crucial.
  • Overcoming current challenges will unlock the full capabilities of this technology.