Dyslipidemia in retinal metabolic disorders

Zhongjie Fu1,2, Chuck T Chen3, Gael Cagnone4,5

  • 1Department of Ophthalmology, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA.

EMBO Molecular Medicine
|September 6, 2019
PubMed
Summary

Photoreceptors, the retina's light-sensing cells, have high energy demands fueled by lipids. Understanding this lipid metabolism is key to treating retinal neurovascular disorders.

Related Concept Videos

Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis10:19

Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis

This technique describes real time recording of oxygen consumption and extracellular acidification rates in explanted mouse retinal tissues using an extracellular flux analyzer.
9.9K
What is Metabolism?00:52

What is Metabolism?

Overview
131.1K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.2K
An Introduction to Cell Metabolism10:19

An Introduction to Cell Metabolism

In cells, critical molecules are either built by joining together individual units like amino acids or nucleotides, or broken down into smaller components. Respectively, the reactions responsible for this are referred to as anabolic and catabolic. These reactions require or produce energy typically in the form of a “high-energy” molecule called ATP. Together, these processes make up “Cell Metabolism,” and are hallmarks of healthy, living cells.JoVE’s introduction...
44.6K
Preparation of Retinal Samples for Volume Electron Microscopy03:48

Preparation of Retinal Samples for Volume Electron Microscopy

This protocol describes the detailed steps for preparing retinal samples for volume electron microscopy, focusing on the structural features of retinal photoreceptor...
1000
Preparation of Mouse Retinal Cryo-sections for Immunohistochemistry05:25

Preparation of Mouse Retinal Cryo-sections for Immunohistochemistry

This report describes comprehensive methods for preparing frozen mouse retina sections for immunohistochemistry (IHC). Methods described include dissection of the ocular posterior cup, paraformaldehyde fixation, embedding in Optimal Cutting Temperature (OCT) media and tissue orientation, sectioning and...
30.1K