Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue06:36

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

7.4K
Here, we present a protocol of elastic staining to identify elastic fibers in pT3N0M0 gastric cancer tissues on formalin-fixed, paraffin-embedded sections. Subsequently, we describe a method to determine whether tumor cells invade beyond the elastic...
7.4K
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

6.2K
Simple and accessible methods were developed to measure the motor aspect of cancer-related fatigue objectively and quantitatively. We describe, in detail, ways to administer the physical fatigue test using a simple handgrip device as well as methods to calculate fatigue...
6.2K
Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines08:42

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

10.7K
The current protocol describes methods to establish patient-derived xenograft (PDX) models and primary cancer cell lines from surgical gastric cancer samples. The methods provide a useful tool for drug development and cancer biology...
10.7K
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

11.5K
This protocol describes the value of dual energy CT and PET/CT imaging methods in tumor imaging and efficacy evaluation. This article demonstrates the research methods and results acquired by dual energy CT and PET/CT to evaluate the gene regulation and targeted treatment of gastric cancer peritoneal...
11.5K
Review and Preview01:10

Review and Preview

8.3K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.3K
Review and Preview01:13

Review and Preview

10.9K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
10.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shifting the Timeline of Esophageal Adenocarcinoma: The Interplay of Lifestyle, Comedication, and Genetics.

United European gastroenterology journal·2026
Same author

Systematic assessment for potential endogenous normalizers for microRNA analysis in fecal samples.

Scientific reports·2026
Same author

Clinical, Dietary, Lifestyle and Genetic Factors Associated With Age at Onset of Esophageal Adenocarcinoma.

United European gastroenterology journal·2026
Same author

The gut mycobiome is shaped by interactions with the bacterial community in twins.

iScience·2026
Same author

Liver Transplantation After Immune Checkpoint Inhibition in Hepatocellular Carcinoma-Data From the Multinational LITCHI Registry.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

Multicenter study of bleeding and thromboembolic events with durvalumab tremelimumab vs. atezolizumab and bevacizumab in advanced HCC.

JHEP reports : innovation in hepatology·2026

Related Experiment Video

Updated: Jan 20, 2026

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
06:36

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Published on: May 1, 2019

7.4K

Review: Gastric cancer-Clinical aspects.

Marino Venerito1, Alexander Link1, Theodoros Rokkas2

  • 1Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.

Helicobacter
|September 6, 2019
PubMed
Summary

Gastric cancer remains a major global health challenge. Early Helicobacter pylori treatment and endoscopic surveillance for intestinal metaplasia can reduce risk, while new therapies show promise for advanced cases.

Keywords:
Helicobacter pyloricancer of the esophagogastric junctionepidemiologygastric cancersurveillancetherapy

More Related Videos

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.2K
Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
08:42

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

Published on: July 19, 2019

10.7K

Related Experiment Videos

Last Updated: Jan 20, 2026

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
06:36

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Published on: May 1, 2019

7.4K
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.2K
Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
08:42

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

Published on: July 19, 2019

10.7K

Area of Science:

  • Oncology
  • Gastroenterology
  • Epidemiology

Background:

  • Gastric cancer (GC) is a leading cause of cancer death worldwide, with concerning incidence trends in younger populations in the USA.
  • Helicobacter pylori infection is a significant risk factor, and its eradication shows potential for GC risk reduction, especially with long-term follow-up.
  • Preneoplastic conditions like intestinal metaplasia (IM) require ongoing surveillance, as highlighted by updated guidelines (MAPS II).

Purpose of the Study:

  • To review current trends, risk factors, and management strategies for gastric cancer.
  • To evaluate the efficacy of novel therapeutic agents and diagnostic markers in advanced GC.
  • To explore the potential of organoid cultures for personalized therapy response testing.

Main Methods:

  • Analysis of global cancer statistics and epidemiological trends.
  • Review of clinical trial data for first-line, second-line, and third-line treatments in advanced GC.
  • Investigation of genetic fusions (CLDN18-ARHGAP26/6) in relation to GC prognosis and treatment response.
  • Assessment of organoid culture models for therapeutic applications.

Main Results:

  • Helicobacter pylori eradication was associated with reduced GC risk, particularly in older individuals treated over 10 years prior.
  • Patients with incomplete-type intestinal metaplasia benefit from endoscopic surveillance post-H. pylori eradication.
  • First-line ramucirumab and second-line pembrolizumab failed to improve overall survival (OS) in metastatic/advanced GC.
  • Trifluridine/tipiracil demonstrated a modest OS improvement in third-line treatment.
  • CLDN18-ARHGAP26/6 fusion predicted worse outcomes and lack of benefit from standard chemotherapy in Chinese GC patients.

Conclusions:

  • Effective management of H. pylori infection and endoscopic surveillance are crucial for gastric cancer prevention and early detection.
  • Current treatment paradigms for advanced GC show limited efficacy, with trifluridine/tipiracil offering a survival benefit in later lines of therapy.
  • Novel biomarkers like CLDN18-ARHGAP26/6 fusion hold prognostic and predictive value, and organoid models show promise for future personalized treatment strategies.