Related Experiment Video
Updated: Jan 20, 2026

Quantifying Agonist Activity at G Protein-coupled Receptors
Published on: December 26, 2011
[Semaglutide, once weekly GLP-1 receptor agonist (Ozempic®)]
1Service de Diabétologie, Nutrition et Maladies métaboliques et Unité de Pharmacologie clinique, CHU Liège.
Abstract:
Semaglutide (Ozempic®) is a new once-weekly agonist of glucagon-like peptide-1 receptors (GLP-1 AR) indicated in the treatment of type 2 diabetes (T2D). Phase III clinical trials of the SUSTAIN programme demonstrated both the efficacy and safety of semaglutide in patients with T2D treated by diet and exercise, oral antidiabetic agents or even insulin. Direct and indirect comparative clinical trials showed that semaglutide (subcutaneous 0.5 or 1.0 mg once weekly) exerts a better glucose-lowering activity and a greater weight loss than other GLP-1 AR. Presented as prefilled pens for subcutaneous injection, semaglutide is currently reimbursed in Belgium after failure of antidiabetic therapy including metformin (HbA1c superior to 7,5 % or 58 mmol/mol) in T2D patients with body mass index ? 30 kg/m².
Related Concept Videos
11:45Quantifying Agonist Activity at G Protein-coupled Receptors
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Drug-Receptor Interaction: Agonist
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous...
02:07Stimulation of Dorsal Root Ganglion Sensory Neurons Using a Neuropeptide Receptor Agonist
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
08:11Measuring Caenorhabditis elegans Sensitivity to the Acetylcholine Receptor Agonist Levamisole
