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Related Concept Videos

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment06:47

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We describe here methods for neonatal capsaicin treatment to induce atopic dermatitis in rats and exposure of vaporized formaldehyde to investigate the effects of formaldehyde inhalation on atopic...
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Dermatitis herpetiformis (DH) is a chronic inflammatory condition characterized by an autoimmune reaction between IgA and epidermal transglutaminase (eTG). DH develops in a very small portion of gluten-sensitive and/or celiac patients. The results of this study indicate that DH can also develop in a rhesus monkey host with symptoms of idiopatic...
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Evaluating the Function of the Foot Core System in the Elderly08:25

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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis08:25

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Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults14:39

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Related Experiment Video

Updated: Jan 20, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

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Atopic dermatitis in elderly adults.

Frédéric Dezoteux1, Bellissen Astrid1, Marie Chuffard1

  • 1Department of Dermatology, University Hospital of Lille, University of Lille, Lille, France.

European Journal of Dermatology : EJD
|September 6, 2019
PubMed
Summary

Atopic dermatitis (AD) in adults over 45 is not well understood. While age doesn't affect treatment response to cyclosporine A (CsA), older adults may experience more side effects, indicating careful monitoring is needed.

Keywords:
adultsatopic dermatitiscyclosporine A

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Evaluating the Function of the Foot Core System in the Elderly
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Last Updated: Jan 20, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Evaluating the Function of the Foot Core System in the Elderly
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Evaluating the Function of the Foot Core System in the Elderly

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Area of Science:

  • Dermatology
  • Immunology
  • Geriatric Medicine

Background:

  • Atopic dermatitis (AD) in adults over 45 years (AD≥45) remains understudied.
  • Understanding AD phenotypes and treatment responses in this demographic is crucial.

Purpose of the Study:

  • To investigate variations in AD phenotype based on onset patterns in AD≥45 patients.
  • To determine if patient age influences the response to cyclosporine A (CsA) treatment.

Main Methods:

  • A retrospective monocentric study included 409 AD<45 and 124 AD≥45 patients.
  • AD≥45 patients were categorized into subgroups based on AD onset: persistence, recurrence, or adult-onset.
  • Cyclosporine A (CsA) treatment data was analyzed for efficacy and tolerability.

Main Results:

  • AD phenotype and severity were similar across onset patterns in AD≥45 patients, except for rarer head/neck involvement in adult-onset AD.
  • CsA efficacy was comparable between AD≥45 and younger AD patients.
  • Older AD patients (AD≥45) showed a higher incidence of increased serum creatinine levels under CsA treatment.

Conclusions:

  • AD onset patterns do not significantly alter demographic or clinical characteristics in older adults, with a noted exception for head and neck lesion prevalence.
  • CsA response is not age-dependent, but tolerability may be reduced in patients over 45.
  • Clinical management of AD in older adults requires consideration of potential age-related differences in drug tolerance.