Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multidirectional interactions in an Mls-disparate response.

J Goldbach1, H Kirchner, E Kölsch

  • 1Institut für Immunologie, Universität Münster, FRG.

Journal of Immunogenetics
|February 1, 1988
PubMed
Summary

Murine T cell clone E11 interactions reveal that gamma-interferon (gamma-IFN) production is key in Mls-disparate responses. This cytokine regulates feedback mechanisms essential for cell communication.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

T cell mediated antibody invariance in an immune response against a bacterial carbohydrate antigen requires CD28/B7-1 costimulation.

Developmental immunology·2002
Same author

Prostaglandins, but not tumor-derived IL-10, shut down concomitant tumor-specific CTL responses during murine plasmacytoma progression.

International journal of cancer·2001
Same author

T-cell enforced invariance of the antibody repertoire in the immune response against a bacterial carbohydrate antigen.

Scandinavian journal of immunology·2001
Same author

The role of interleukin-4 in the regulation of sequential isotype switch from immunoglobulin G1 to immunoglobulin E antibody production.

Scandinavian journal of immunology·2000
Same author

Involvement of CD28 cosignalling in the T cell-mediated suppression of the IgG antibody response against the TI-2 antigen alpha(1-->3) dextran.

Immunobiology·1999
Same author

The J558 VH CDR3 region contributes little to antibody avidity; however, it is the recognition element for cognate T cell control of the alpha(1-->3) dextran-specific antibody response.

International immunology·1999

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Murine T cell clone E11 aids analysis of Mls-disparate responses.
  • Mixed lymphocyte cultures are crucial for understanding immune cell interactions.

Purpose of the Study:

  • To analyze multidirectional interactions in Mls-disparate responses using the E11 T cell clone.
  • To elucidate the role of gamma-interferon (gamma-IFN) in these cellular interactions.

Main Methods:

  • Utilized a murine T cell clone (E11) derived from a mixed lymphocyte culture.
  • Observed T cell proliferation, B cell differentiation, and macrophage inhibition upon stimulation.

Main Results:

  • E11 T cells proliferated when stimulated by Mls-disparate macrophages or B cells.
  • E11 T cells inhibited macrophage spreading and differentiation, and prevented mediator production.
  • These effects were linked to Mlsa,d,e-specific induction of gamma-interferon (gamma-IFN) in E11 T cells.

Conclusions:

  • Gamma-interferon (gamma-IFN) production is induced in T cells during Mls-disparate responses.
  • Gamma-interferon (gamma-IFN) acts as a feedback regulator in Mls-disparate cell interactions.
  • This cytokine plays an essential role in mediating these complex cellular communications.

Related Experiment Videos