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Related Concept Videos

Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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Auricular Acupressure as an Adjuvant Treatment for Wheezing in Stable Chronic Obstructive Pulmonary Disease02:34

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Chronic Obstructive Pulmonary Disease-I: Introduction01:20

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Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
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Chronic Obstructive Pulmonary Disease-V: Management01:29

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Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
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Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease.

Dinesh Devadoss1, Christopher Long1, Raymond J Langley2

  • 1Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.

American Journal of Respiratory Cell and Molecular Biology
|September 6, 2019
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) may play a crucial role in chronic obstructive pulmonary disease (COPD) development by regulating airway inflammation. Further research into lncRNAs could lead to new COPD biomarkers and therapies.

Keywords:
cigarette smokeinflammationlncRNAsmitochondriasenescence

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Chronic Obstructive Pulmonary Disease
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Area of Science:

  • Pulmonary Medicine
  • Molecular Biology
  • Genetics

Background:

  • Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and lung damage due to chronic airway inflammation from environmental exposures.
  • Gene-environment interactions significantly influence COPD onset and progression, with transcriptomic and epigenetic factors in lung cells playing key roles.
  • While candidate susceptibility genes are known, the role of noncoding RNAs, especially long noncoding RNAs (lncRNAs), in COPD pathogenesis is emerging.

Purpose of the Study:

  • To review the features of long noncoding RNAs (lncRNAs) implicated in regulating airway inflammation.
  • To explore the potential association of lncRNAs with the pathogenesis of chronic obstructive pulmonary disease (COPD).
  • To highlight the need for novel biomarkers and therapeutic strategies for COPD.

Main Methods:

  • Literature review focusing on noncoding RNAs, specifically lncRNAs.
  • Analysis of studies investigating molecular mechanisms in airway inflammation and COPD.
  • Synthesis of current knowledge on lncRNA function in response to environmental stimuli like cigarette smoke.

Main Results:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in cellular responses to environmental toxins.
  • lncRNAs may modulate key pathways involved in mucus hyperreactivity and airway remodeling in COPD.
  • Evidence suggests lncRNAs are involved in the inflammatory processes triggered by cigarette smoke exposure.

Conclusions:

  • Long noncoding RNAs (lncRNAs) represent a significant, yet underexplored, factor in chronic obstructive pulmonary disease (COPD) development.
  • Understanding lncRNA functions offers potential for identifying new diagnostic biomarkers and therapeutic targets for COPD.
  • Further investigation into lncRNAs is critical given the growing global burden of COPD.