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Updated: Jan 20, 2026

Ex Vivo Expansion of Hematopoietic Stem Cells from Human Umbilical Cord Blood-derived CD34+ Cells Using Valproic Acid
Published on: April 11, 2019
El ácido valproico como agente sensibilizador al tratamiento anticáncer
Gabriela Rebeca Luna-Palencia1, José Correa-Basurto2, Ismael Vásquez-Moctezuma3
1Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Departamento de Biotecnología. Ciudad de México, México.
Abstract:
Valproic acid is an antiepileptic drug with more than 50 years of clinical use. In the past decade, its anticancer effects were discovered. Analyses in groups of patients who used this drug for years have shown that it decreases the frequency of head and neck cancer. Recent studies show the anticancer effect of combining valproic acid with chemotherapy, biological therapy and antioxidant systems inhibitors, with exceptional results. In this review, we analyze the metabolism of valproic acid and its application against cancer.
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