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Related Experiment Video

Updated: Jan 20, 2026

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[Transcatheter mitral valve replacement: current status].

J Vogelhuber, M Weber, J-M Sinning

  • 1Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Venusberg - Campus 1, 53127, Bonn, Deutschland. georg.nickenig@ukbonn.de.

Herz
|September 6, 2019
PubMed
Summary
This summary is machine-generated.

Mitral regurgitation (MR) affects older patients and is often treated with medication. For persistent symptoms, surgical or transcatheter mitral valve repair or replacement (TMVR) may be considered, with TMVR showing promise.

Keywords:
Heart failureHeart valve diseasesHeart-TeamMitral valve insufficiencyTranscatheter mitral valve replacement

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A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
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Area of Science:

  • Cardiology
  • Cardiovascular Surgery
  • Interventional Cardiology

Background:

  • Mitral regurgitation (MR) is the second most common valvular heart disease, primarily affecting elderly individuals.
  • Optimal medical therapy is the first-line treatment for secondary MR, with surgical or transcatheter repair indicated if symptoms persist.
  • Surgical intervention is crucial for symptomatic primary MR in eligible patients, while transcatheter repair is an option for high-risk individuals.

Purpose of the Study:

  • To review current treatment strategies for mitral regurgitation (MR), including medical, surgical, and transcatheter approaches.
  • To highlight the emerging role and ongoing research in transcatheter mitral valve replacement (TMVR) for native MR.
  • To emphasize the importance of a patient-specific, interdisciplinary approach to MR treatment.

Main Methods:

  • Review of current guidelines and clinical practices for managing mitral regurgitation.
  • Discussion of surgical and transcatheter mitral valve repair techniques.
  • Overview of the development and clinical evaluation of transcatheter mitral valve replacement (TMVR) prostheses for native MR.

Main Results:

  • Transcatheter mitral valve repair (edge-to-edge) is a viable option for high-risk patients with primary MR.
  • Transcatheter mitral valve replacement (TMVR) is an emerging treatment option, with dedicated prostheses under clinical evaluation.
  • No TMVR prosthesis currently holds CE certification, and all are undergoing pivotal trials.

Conclusions:

  • Treatment decisions for MR require a patient-specific approach by an interdisciplinary heart team.
  • Transcatheter mitral valve repair and replacement represent evolving therapeutic options for MR.
  • Further clinical evaluation is necessary to establish the role and efficacy of TMVR for native MR.