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Updated: Jan 20, 2026

Stimulation of Dorsal Root Ganglion Sensory Neurons Using a Neuropeptide Receptor Agonist
In Vitro Optogenetic Characterization of Neuropeptide Release from Prefrontal Cortical Somatostatin Neurons
Nigel C Dao1, Dakota F Brockway2, Nicole A Crowley2
1Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802.
Abstract:
Somatostatin is a neuropeptide thought to play a role in a variety of neuropsychiatric disorders, and is important for healthy aging and behavioral resiliency. Physiological conditions underlying somatostatin peptidergic release are not well-defined. Using a combination of optogenetic and biochemical approaches in transgenic mice, we demonstrate an assay for the induction and inhibition of somatostatin release in mouse acute brain slices.
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