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Psychiatric comorbidity in Intermittent Explosive Disorder.

Emil F Coccaro1

  • 1Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA.

Journal of Psychiatric Research
|September 6, 2019
PubMed
Summary

Intermittent Explosive Disorder (IED) frequently co-occurs with other psychiatric conditions like bipolar and anxiety disorders. The onset of IED often precedes these conditions, supporting its distinct diagnosis when comorbid.

Keywords:
AggressionComorbidityIED

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Epidemiology

Background:

  • Intermittent Explosive Disorder (IED) is a psychiatric disorder characterized by recurrent, impulsive aggressive outbursts.
  • Understanding the comorbidity of IED with other psychiatric disorders is crucial for diagnostic validity and treatment planning.

Purpose of the Study:

  • To investigate the psychiatric comorbidity patterns of Intermittent Explosive Disorder (IED).
  • To explore the validity of IED by comparing its comorbidity to other established psychiatric disorders.
  • To examine the temporal relationship between IED onset and comorbid conditions, and aggression levels.

Main Methods:

  • Analysis of data from the National Comorbidity Study - Revised (NCS-R) and its Adolescent Supplement (NCS-AS).
  • Inclusion of a large clinical research dataset (n=1640).
  • Comparison of comorbidity rates and aggression scores between IED participants and those with other disorders.

Main Results:

  • Comorbidity rates in IED were similar to those in other non-IED disorders.
  • IED was significantly comorbid with bipolar, depressive, anxiety, substance use, and post-traumatic stress disorders.
  • The onset of IED typically preceded the onset of comorbid disorders, and aggression scores were highest in individuals with both IED and a comorbid disorder.

Conclusions:

  • Comorbidity patterns of IED are comparable to those of other established psychiatric disorders.
  • The findings support the validity of diagnosing IED alongside other comorbid conditions, especially when IED onset precedes other disorders.
  • Higher aggression scores in individuals with comorbid IED suggest the importance of recognizing and treating both conditions concurrently.