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Updated: Jan 20, 2026

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

Assessing Cachexia Acutely after Autologous Stem Cell Transplant.

Lindsey J Anderson¹, Chelsea Yin¹, Raul Burciaga¹

¹Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA.

|September 7, 2019

Summary

Autologous hematopoietic stem cell transplantation (AHCT) can impair physical function and reduce quality of life. Acute effects on body composition and fatigue were observed, but not inflammation or testosterone levels.

Keywords:

hematopoietic stem cell transplant muscle function muscle wasting testosterone

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Last Updated: Jan 20, 2026

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

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Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

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Published on: October 3, 2018

Area of Science:

Hematology
Oncology
Transplantation Medicine

Background:

Autologous hematopoietic stem cell transplantation (AHCT) is a key treatment for hematologic malignancies.
AHCT can lead to functional impairment, fatigue, and reduced quality of life (QOL).
The acute impact of AHCT on physical function, body composition, and metabolic factors is not well understood.

Purpose of the Study:

To characterize the acute effects of AHCT on physical function, body composition, QOL, energy expenditure, cytokines, and testosterone.
To investigate the relationship between these factors and outcomes post-AHCT.

Main Methods:

Prospective study assessing patients before (PRE) and 30 ± 10 days after (FU) AHCT.
Included patients with multiple myeloma (n=15) and non-Hodgkin lymphoma (n=6).
Evaluated outcomes including Six-Minute Walk Test (6MWT), body composition (lean/fat mass), QOL, energy expenditure, cytokines (IL-1β, IL-6, TNF), and testosterone.

Main Results:

Significant decreases in 6MWT distance (p=0.014), lean mass (p=0.002), and fat mass (p=0.02) were observed.
Increased nausea and fatigue were reported at FU (p=0.039).
No significant changes in cytokines, energy expenditure, or testosterone were found; these were not associated with functional impairment.

Conclusions:

Acute functional impairment after AHCT is not explained by changes in cytokines, energy expenditure, or testosterone.
Recent weight loss and steroid exposure predict reduced aerobic capacity and worse physical function post-AHCT.
Targeting nutritional status and myopathy may mitigate adverse effects following AHCT.