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Osteopathic Manipulation Treatment Improves Cerebro-splanchnic Oximetry in Late Preterm Infants

Benedetta Marinelli1, Francesca Pluchinotta2, Vincenzo Cozzolino1

  • 1Department, Italian Academy of Traditional Osteopathy (AIOT), 65100 Pescara, Italy.

Molecules (Basel, Switzerland)
|September 7, 2019
PubMed

Insights

Osteopathic manipulation treatment (OMT) improved brain and gut oxygenation in late preterm infants without side effects. This suggests OMT may be beneficial for infant development and warrants further study.

Area of Science:

  • Neonatal physiology
  • Clinical research
  • Osteopathic medicine

Background:

  • Late preterm (LP) infants may experience altered cerebro-splanchnic oxygenation.
  • Near-infrared spectroscopy (NIRS) can monitor tissue oxygenation and hemodynamics non-invasively.
  • Osteopathic manipulation treatment (OMT) is a potential intervention for LP infants.

Purpose of the Study:

  • To evaluate the effectiveness and side-effects of OMT on cerebro-splanchnic oximetry in LP infants.
  • To assess OMT's impact on tissue oxygenation and hemodynamic redistribution.
  • To utilize NIRS for real-time physiological monitoring.

Main Methods:

  • An observational pretest-test study involving 18 LP infants receiving OMT on the 7th postnatal day.
  • NIRS monitoring was conducted at three time-points: before (T0), during (T1), and after (T2) OMT.
  • Key parameters measured included cerebral (c) and splanchnic (s) regional oximetry (rSO2), fractional tissue oxygen extraction (FTOE), and cerebro-splanchnic oxygen reserve (CSOR).

Main Results:

  • Cerebral rSO2 and cFTOE significantly improved from T0 to T2 (P < 0.001).
  • Splanchnic rSO2 initially decreased and sFTOE increased during OMT (T0-T1), then both significantly improved (T1-T2).
  • Cerebro-splanchnic oxygen reserve (CSOR) significantly increased from T0 to T2 (P < 0.05).

Conclusions:

  • OMT enhances cerebro-splanchnic oxygenation and hemodynamic redistribution in LP infants.
  • No adverse clinical or laboratory effects were observed.
  • Further randomized controlled trials are recommended to compare OMT with standard rehabilitation programs.

Keywords:
NIRSbrainlate pretermosteopathysplanchnic

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