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Epigenetic Modification in Coronary Atherosclerosis: JACC Review Topic of the Week

Barbara Rizzacasa1, Francesca Amati2, Francesco Romeo3

  • 1Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.

Journal of the American College of Cardiology
|September 7, 2019
PubMed

Insights

Epigenetics, influenced by environmental factors, plays a key role in coronary artery disease (CAD) and acute myocardial infarction (AMI). Understanding these epigenetic changes is crucial for CAD development insights.

Area of Science:

  • Cardiovascular Science
  • Epigenetics
  • Genetics

Background:

  • Coronary artery disease (CAD) and acute myocardial infarction (AMI) are leading global causes of death.
  • Genetic and lifestyle factors influence CAD and MI risk.
  • Epigenetics is emerging as a critical factor in CAD development.

Purpose of the Study:

  • To discuss major epigenetic changes contributing to CAD.
  • To review recent discoveries on environmental influences on epigenetic profiles in CAD.

Main Methods:

  • Literature review of epigenetic mechanisms in CAD.
  • Analysis of environmental impacts on epigenetic modifications.

Main Results:

  • Epigenetic patterns are sensitive to environmental exposures.
  • These modifications can alter gene expression relevant to CAD.
  • Specific epigenetic changes are linked to CAD pathogenesis.

Conclusions:

  • Epigenetics is a significant mediator between environment and CAD risk.
  • Further research into environmental epigenetics can reveal novel therapeutic targets for CAD and AMI.

Keywords:
coronary artery diseaselong noncoding RNAmethylationmicroRNAmyocardial infarction

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