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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Acute Stroke Interventions Performed by Cardiologists: Initial Experience in a Single Center
Marius Hornung1, Stefan C Bertog1, Iris Grunwald2
1CardioVascular Center Frankfurt, Sankt Katharinen Hospital, Frankfurt, Germany.
Insights
Interventional cardiologists successfully performed acute stroke interventions, achieving high technical success (93%) and favorable clinical outcomes (61%) in patients with large-vessel occlusions. This demonstrates the safety and efficacy of utilizing cardiology centers for timely stroke treatment.
Area of Science:
- Cardiology
- Neurology
- Interventional Radiology
Background:
- Dedicated interventional stroke centers are scarce.
- Interventional cardiology infrastructure can facilitate rapid, 24/7 stroke intervention.
- Leveraging existing catheterization labs can improve access to acute stroke treatment.
Purpose of the Study:
- To assess the technical and clinical success of acute stroke interventions.
- To evaluate the role of interventional cardiology centers in stroke treatment.
- To determine the feasibility of rapid stroke intervention in a cardiology setting.
Main Methods:
- Retrospective analysis of 70 consecutive acute stroke interventions for large-vessel occlusions (July 2012-July 2018).
- Evaluation of procedural times, recanalization rates, and complication data.
- Assessment of 30-day mortality and 3-month functional outcomes using modified Rankin Scale.
Main Results:
- Technical recanalization success (TICI 2b/3) was achieved in 93% of patients.
- Mean door-to-vascular access time was 64 minutes; mean time to lesion crossing was 26 minutes.
- Favorable clinical outcome (mRS 0-2) at 3 months was 61%, with 30-day mortality at 18%.
Conclusions:
- Interventional cardiologists can safely perform acute stroke interventions.
- High technical and clinical success rates are achievable in a cardiology center.
- Cardiology networks offer a viable solution for improving rapid access to stroke intervention.
Objectives:
The aim of this study was to evaluate the technical and clinical success of acute stroke interventions performed in our interventional cardiology center.
Background:
Dedicated interventional stroke centers remain limited. Interventional cardiologists have established networks of catheterization laboratories and the necessary infrastructure to provide around the clock interventional therapy. These networks may also provide the currently lacking universal rapid access to prompt stroke intervention.
Methods:
Between July 2012 and July 2018, 70 consecutive patients underwent acute stroke intervention for large-vessel occlusions. Seventeen patients (24%) had tandem or multiple vessel occlusions. The majority (n = 63, 90%) were admitted via our local stroke unit, and 7 (10%) patients were transferred from other regional referral centers.
Results:
In 43 (61%) patients, systemic fibrinolytic therapy was started after baseline imaging. Mean time between symptom onset and arrival to the cath lab was 138 min; mean door-to-vascular access time was 64 min; mean time between cath lab activation and its operational readiness was 13 min. In all cases, access to supra-aortic vessels was achieved. Mean time between femoral arterial puncture and lesion crossing was 26 min. Stent implantation for extracranial stenosis or dissection was performed in 14 (20%) cases. Thrombectomy of intracranial occlusions was done with a stent retriever (n = 64, 91%) or an aspiration system (n = 14, 20%). In 20 (28%) cases, a combination of techniques was used. Recanalization was technically successful (Thrombolysis In Cerebral Infarction flow grade 2b or 3) in 65 (93%) patients. The 30-day mortality was 18% (n = 13). Favorable clinical outcome, defined as a modified Rankin Scale score of 0 to 2, was achieved in 61% at 3-month follow-up.
Conclusions:
Acute stroke interventions can be performed safely and with high technical and clinical success by experienced interventional cardiologists.
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