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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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Deep Transcranial Magnetic Stimulation to Alleviate Symptoms of Post-Traumatic Stress Disorder03:15

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Source: Tendler, A., et al. How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression. J. Vis. Exp. (2017)This video demonstrates the use of deep transcranial magnetic stimulation (dTMS) to alleviate symptoms of post-traumatic stress disorder, or PTSD. It begins by identifying reduced activity in the medial prefrontal cortex (mPFC) as a key factor contributing to the overactivation of the amygdala and heightened fear responses. By applying targeted...
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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder05:49

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Here we describe the detailed methodology required to conduct stress-enhanced fear learning (SEFL) experiments, a preclinical model of post-traumatic stress disorder, in both rats and mice. The model utilizes aspects of Pavlovian fear conditioning and freezing as an index of enhanced fear in rodents.
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An Introduction to Modeling Behavioral Disorders and Stress10:17

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Recently, it has been discovered that behavioral conditions such as, depression, anxiety and stress-response have a neurological basis. Understanding the biological underpinnings of these conditions may help scientists in developing more effective therapies to treat these disorders. Typically, rodent models are used in this field and behavioral scientists create these models using interventions like drug administration or surgery. It is important to understand how to create and evaluate rodent...
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Using Retinal Imaging to Study Dementia09:17

Using Retinal Imaging to Study Dementia

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The retina shares prominent similarities with the brain and thus represents a unique window to study vasculature and neuronal structure in the brain non-invasively. This protocol describes a method to study dementia using retinal imaging techniques. This method can potentially aid in diagnosis and risk assessment of...
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Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

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This systematic protocol describes a new animal model of post-traumatic epilepsy after repetitive mild traumatic brain injury. The first part details steps for traumatic brain injury induction using a modified weight drop model. The second part provides instructions on the surgical approach for single- and multi-channel electroencephalographic data acquisition...
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Related Experiment Video

Updated: Jan 20, 2026

Post-traumatic Stress Disorder
01:27

Post-traumatic Stress Disorder

488

The Interplay Between Post-traumatic Stress Disorder and Dementia: A Systematic Review.

Philippe Desmarais1, Danielle Weidman2, Andréanne Wassef3

  • 1Department of Medicine, Division of Geriatrics (PD, MPT,QDN), Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; Department of Neurosciences (PD, MPT), Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|September 7, 2019
PubMed
Summary

Post-traumatic stress disorder (PTSD) increases dementia risk, while dementia can trigger delayed PTSD in trauma survivors. This review confirms a two-way link between PTSD and dementia.

Keywords:
Alzheimer's diseaseAnxietydementiafrontotemporal lobar degenerationneuropsychiatric symptomspost-traumatic stress disorder

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Deep Transcranial Magnetic Stimulation to Alleviate Symptoms of Post-Traumatic Stress Disorder
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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

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Last Updated: Jan 20, 2026

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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
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Area of Science:

  • Neuroscience
  • Psychiatry
  • Gerontology

Background:

  • Post-traumatic stress disorder (PTSD) is linked to increased dementia risk.
  • Delayed PTSD onset in dementia patients suggests a complex relationship.

Purpose of the Study:

  • To review studies on the PTSD-dementia association.
  • To assess evidence for a bidirectional relationship between PTSD and dementia.

Main Methods:

  • Systematic review of observational studies from Web of Science Core.
  • Extracted data on populations, trauma, onset timing, and outcomes.
  • Characterized temporal relationships between trauma and condition onset.

Main Results:

  • 25 articles reviewed; 14 showed PTSD increasing dementia risk.
  • 11 articles reported delayed PTSD onset with dementia.
  • Early-life trauma (e.g., combat) was common; mid-life PTSD increased late-onset dementia risk.

Conclusions:

  • PTSD and dementia exhibit a bidirectional relationship.
  • PTSD elevates the risk for late-onset dementia.
  • Dementia can precipitate delayed-onset PTSD in individuals with prior trauma.