Pediatric NUT Carcinoma Is a Rare and Challenging Tumor: Single Center Experience of Five Children
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Updated: Jan 20, 2026
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Published on: December 4, 2023
Maya Prasad1,2, Akshay Baheti3,2, Mukta Ramadwar4,2
1Department of Pediatric Oncology, Tata Memorial Hospital, Mumbai, India Maya.prasad@gmail.com.
Background:
Nuclear protein of the testis (NUT) carcinoma is a rare and aggressive malignancy associated with rearrangements of the nuclear protein of the testis (NUT) gene on chromosome 15q14. Because of its rarity, this tumor is often underdiagnosed and underreported, and there is limited literature regarding its biology and optimal management.
Methods And Results:
We report our experience of five patients with pediatric NUT carcinoma, all of whom presented with midline head and neck mass. In spite of aggressive multimodality treatment, only one patient survives.
Conclusion:
NUT carcinoma has a dismal prognosis in spite of aggressive multimodality management (surgery and adjuvant chemotherapy and/or radiation). Novel strategies are required to improve outcomes of patients with this tumor.
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