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Related Experiment Video

Updated: Jan 20, 2026

Bipolar Disorder
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CADASIL and Bipolar Affective Disorder.

Hong Kai Lim1, Zachary A Millar, Rashid Zaman

  • 1School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Psychiatria Danubina
|September 7, 2019
PubMed
Summary
This summary is machine-generated.

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), a genetic disorder, rarely presents with bipolar disorder. This case highlights the importance of considering mood disorders in CADASIL patients.

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Area of Science:

  • Neurology
  • Psychiatry
  • Genetics

Background:

  • Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare genetic disorder caused by NOTCH3 gene mutations.
  • Clinical features typically involve neurological symptoms like strokes and migraines, but psychiatric manifestations, including mood disturbances, are also recognized.

Observation:

  • This report details a case of Bipolar Affective Disorder (BD) in a British woman with a family history of CADASIL.
  • Manic symptoms and BD are infrequently documented in CADASIL, with limited prior case descriptions and psychiatric evaluation details.

Findings:

  • The case offers insights into diagnosing and managing BD within the context of CADASIL.
  • Potential shared etiological pathways between BD and CADASIL are suggested by similarities in imaging, genetics, and therapeutic responses.

Implications:

  • BD in CADASIL warrants increased attention from both psychiatric and non-psychiatric specialists.
  • Further research is necessary to elucidate the pathological significance of this comorbidity and explore common underlying mechanisms.