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Active behaviour during early development shapes glucocorticoid reactivity.

Luis A Castillo-Ramírez1, Soojin Ryu1, Rodrigo J De Marco2,3

  • 1Developmental Neurobiology of Resilience, German Resilience Center, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, 55128, Mainz, Germany.

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This summary is machine-generated.

Early life stress, like involuntary swimming, can alter the cortisol stress response in zebrafish. This early experience also impacts behavior and energy efficiency later in life.

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Area of Science:

  • Neuroendocrinology
  • Developmental Biology
  • Behavioral Science

Background:

  • Glucocorticoids are key regulators of the stress response, crucial for adaptation.
  • The impact of early life events on programming the glucocorticoid system remains poorly understood.

Purpose of the Study:

  • To investigate how early developmental stress influences the glucocorticoid response to stress.
  • To examine the long-term behavioral and physiological consequences of early life stress.

Main Methods:

  • Larval zebrafish (Danio rerio) were exposed to involuntary swimming during early development.
  • Cortisol response to homotypic and heterotypic stress was measured.
  • Behavioral assessments included startle reactivity, spontaneous activity, and energy efficiency.

Main Results:

  • Involuntary swimming during early development reconfigured the cortisol response to subsequent stress.
  • Early life stress reduced startle reactivity and increased spontaneous activity.
  • Energy efficiency during active behavior was enhanced following early life stress.

Conclusions:

  • Early life stress can permanently alter the glucocorticoid stress axis.
  • Zebrafish serve as a valuable model for studying the link between early stress and glucocorticoid function.
  • These findings highlight the lasting impact of early environmental factors on stress system programming.