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Updated: Jan 20, 2026

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
Published on: January 18, 2021
Virtual reality exposure therapy for posttraumatic stress disorder (PTSD): a meta-analysis
Oswald D Kothgassner1, Andreas Goreis2,3, Johanna X Kafka1
1Department of Child and Adolescent Psychiatry, Medical University of Vienna, Wien, Austria.
Virtual Reality Exposure Therapy (VRET) shows promise for treating posttraumatic stress disorder (PTSD), performing better than waitlist controls. VRET appears as effective as active comparators for PTSD symptoms.
Area of Science:
- Psychiatry and Behavioral Sciences
- Clinical Psychology
- Medical Technology
Background:
- Virtual Reality Exposure Therapy (VRET) is effective for specific phobias, but its utility for posttraumatic stress disorder (PTSD) remains uncertain.
- Existing research on VRET for PTSD lacks conclusive evidence, necessitating further investigation.
Purpose of the Study:
- To conduct a meta-analysis evaluating the efficacy of VRET for PTSD compared to waitlist and active control conditions.
- To assess the impact of VRET on PTSD symptom severity, as well as secondary outcomes of depressive and anxiety symptoms.
Main Methods:
- A systematic literature search identified nine controlled studies with 296 participants (124 in VRET, 172 in control groups).
- Hedges' *g* was used to calculate differences in PTSD, depressive, and anxiety symptoms post-treatment between VRET and control conditions.
Main Results:
- VRET demonstrated significantly better outcomes than waitlist controls for PTSD symptoms (*g* = 0.62, *p* = 0.017) and depressive symptoms (*g* = 0.50, *p* = 0.008).
- No significant differences were found between VRET and active comparators for PTSD (*g* = 0.25, *p* = 0.356) or depressive symptoms (*g* = 0.24, *p* = 0.340).
- No significant effects were observed for anxiety symptoms.
Conclusions:
- VRET may be a viable treatment option for PTSD, comparable in effectiveness to active comparator therapies.
- Findings should be interpreted cautiously due to the limited number of studies and the predominantly male military participant pool.
- Further controlled trials with diverse trauma types and balanced gender representation are needed to solidify VRET's role in PTSD treatment.
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