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Related Experiment Video

Updated: Jan 20, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
05:05

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Published on: July 18, 2025

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Ventilatory equivalent for oxygen as an extubation outcome predictor: A pilot study.

Troy Ellens1, Ramandeep Kaur2, Kelly Roehl3

  • 1Quality Improvement Systems, James. M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Canadian Journal of Respiratory Therapy : CJRT = Revue Canadienne De La Therapie Respiratoire : RCTR
|September 7, 2019
PubMed
Summary

Ventilatory equivalent for oxygen (VEqO2) may indicate success during spontaneous breathing trials but does not predict extubation outcomes in mechanically ventilated patients. Further research with larger sample sizes is needed to confirm these findings.

Keywords:
mechanical ventilationoxygen consumptionrapid shallow breathing indexspontaneous breathing trialwork of breathing

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Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Mechanical Ventilation

Background:

  • Mechanical ventilation weaning predictors are crucial for timely patient liberation.
  • Ventilatory equivalent for oxygen (VEqO2) is a noninvasive measure of breathing efficiency and work of breathing.
  • VEqO2's utility as a weaning predictor requires further investigation.

Purpose of the Study:

  • To assess differences in VEqO2 between extubation outcome groups.
  • To evaluate VEqO2 as a predictor of successful extubation.

Main Methods:

  • Adult ICU patients (n=34) underwent spontaneous breathing trials (SBT).
  • Metabolic cart measured oxygen consumption (VO2) and ventilatory parameters to calculate VEqO2 and RSBI.
  • Mann-Whitney U test analyzed VEqO2 and RSBI between SBT and extubation pass/fail groups (p < 0.05).

Main Results:

  • VEqO2 was not significantly different between extubation outcome groups (n=20).
  • Patients who passed SBT had higher VEqO2 at midpoint (p=0.035) and end (p=0.017) compared to those who failed.
  • VEqO2 may reflect work of breathing during SBT but not predict post-extubation outcomes.

Conclusions:

  • VEqO2 may differentiate spontaneous breathing trial outcomes but not extubation success.
  • VEqO2 might detect changes in respiratory workload during SBT.
  • Small sample size may have limited the ability to show differences in extubation outcomes.