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Updated: Jan 20, 2026
10:14
Biochemical Assays for Analyzing Activities of ATP-dependent Chromatin Remodeling Enzymes
Published on: October 25, 2014
15.2K
Chromatin-Remodeled State in Lymphoma
Yuxuan Liu1, Yulissa Gonzalez1, Jennifer E Amengual2
1Division of Hematology and Oncology, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, USA.
Current Hematologic Malignancy Reports
|September 7, 2019
Summary
Epigenetic derangements drive lymphoma development by altering chromatin structure. Targeting these epigenetic changes offers new precision medicine strategies for lymphoma patients.
Area of Science:
- Oncology
- Epigenetics
- Hematology
Background:
- Epigenetic alterations are increasingly recognized as drivers of tumorigenesis in various cancers.
- These epigenetic derangements are prevalent in both B cell and T cell lymphomas, influencing tumor biology and clinical presentation.
Purpose of the Study:
- To elucidate how epigenetic derangements lead to a remodeled chromatin state in lymphoma.
- To explain the contribution of these epigenetic changes to the biology and clinical features of lymphoma.
Main Methods:
- Review of existing studies on the functional role of epigenetic derangements in chromatin remodeling and lymphomagenesis.
- Analysis of recent findings identifying specific lymphoma subtypes and associated genetic mutations.
Main Results:
- Haploinsufficiency of CREBBP facilitates malignant transformation, highlighting the need for physiological acetylation levels.
- Identification of the EZB-GC-DLBCL subtype enriched in mutations of CREBBP, EP300, KMT2D, and SWI/SNF complex genes, associated with a worse prognosis.
- Histone modifiers and chromatin-remodeling factors cooperate to influence chromatin state and transcription repression.
Conclusions:
- Epigenetic lesions in histone modifiers are confirmed vulnerabilities in lymphoma.
- Modulating the chromatin state via epigenetic-modifying agents presents precision medicine opportunities for lymphoma patients.
- Targeting epigenetic derangements offers a promising therapeutic avenue for lymphomas.
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