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Related Experiment Video

Updated: Jan 20, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

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Demand for Precision Medicine: A Discrete-Choice Experiment and External Validation Study.

Dean A Regier1,2, David L Veenstra3, Anirban Basu3

  • 1Cancer Control Research - Canadian Centre for Applied Research in Cancer Control (ARCC), BC Cancer, 675 West 10th Avenue, Vancouver, British Columbia, V5Z 1L3, Canada. dregier@bccrc.ca.

Pharmacoeconomics
|September 7, 2019
PubMed
Summary

Public demand for precision medicine is initially weak and price-sensitive due to evidence uncertainty. Clear communication of outcomes is vital for healthcare adoption and alignment with patient preferences.

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Area of Science:

  • Health Economics
  • Genomics
  • Medical Decision Making

Background:

  • Adoption of precision medicine is hindered by limited evidence and unclear clinical guidelines.
  • The impact of these challenges on public demand for precision medicine remains poorly understood.

Purpose of the Study:

  • To estimate public preferences and demand for precision medicine outcomes.
  • To assess how demand for precision medicine changes with an evolving evidence base.

Main Methods:

  • A discrete-choice experiment survey was administered to US adults with recent healthcare experience.
  • An error components mixed logit model was used for statistical analysis.
  • Price elasticity of demand was calculated to estimate demand responsiveness to evidence changes, with external validation using real-world data for a breast cancer gene assay.

Main Results:

  • Survival gains with uncertainty, testing costs, and expert consensus on treatment changes were key patient-valued outcomes.
  • Individuals were willing to pay $1100 for high expert agreement and $265 for increased certainty in life-expectancy gains.
  • Predicted demand for a 21-gene assay closely matched real-world uptake (7% in 2005, 71% in 2014).

Conclusions:

  • The study found external validity for predicted demand.
  • Initial demand for precision medicine is low and price-sensitive due to uncertainty and an immature evidence base.
  • Effective communication of precision medicine outcomes and associated uncertainties is essential for aligning healthcare with patient preferences.